INTRODUCTION AND EPIDEMIOLOGY Print Section Listen Soft tissue sarcomas (STS) are comprised of malignant tumors which arise from tissues of mesodermal origin (e.g., fat, muscle, connective tissue, vessels) excluding bone…
RADIATION THERAPY IN PATIENTS WITH AJCC STAGE III MELANOMA Print Section Listen Radiation therapy (RT) in patients with metastatic melanoma in regional lymph nodes may be used as adjuvant treatment,…
INTRODUCTION Print Section Listen During embryogenesis, melanocytes migrate from the neural crest and eventually are widely distributed throughout skin, mucosa, and other sites. Melanomas arising in noncutaneous sites are a…
INTRODUCTION Print Section Listen This chapter describes the indications for surgery, technical aspects of surgery, and outcomes for patients with metastatic melanoma involving regional lymph nodes (stage III) or distant…
TREATMENTS DIRECTED AT LOCOREGIONAL RECURRENCE AND IN-TRANSIT METASTASES Print Section Listen Locoregional recurrence of a melanoma is defined as recurrence in or around a scar from previous melanoma surgery, or…
INTRODUCTION Print Section Listen Sentinel lymph node (SLN) biopsy is now a standard component of the treatment of many melanomas, and its use is accepted as routine.1,2 So routine, in…
BIOPSY Print Section Listen A skin lesion that is suspicious for melanoma is best removed by excisional biopsy with a 1- to 2-mm clinical lateral margin and a deep margin…
INTRODUCTION Print Section Listen Regional cancer therapies are treatments that direct a therapeutic intervention to a cancer burdened organ or region of the body; they have the collective advantage of…
INTRODUCTION Print Section Listen Cancer is a complex disease capable of manifesting itself as many different disease phenotypes occurring in virtually any tissue of the body. This complexity can be…
“EPIGENETICS”: ORIGIN OF THE WORD Print Section Listen Conrad Hal Waddington is usually credited with modifying the Greek word “epigenesis,” which described a theory of development, into a new term…
