NK Cell-Based Therapies
Fig. 16.1 NK cell-based therapies. (a). NK cells are purified from the peripheral blood of a healthy donor and activated in vitro with cytokines (IL-2 or IL-15) before being injected…
The Human Tumor Microenvironment
Fig. 2.1 Major immunopathological and genetic events occurring during carcinogenesis. Upon chronic inflammatory stimuli exposure, normal cells undergo transformation into precancerous cells. Local inflammation induces recruitment of myeloid-derived cells that…
Concluding Remarks
© Springer International Publishing AG 2018Laurence Zitvogel and Guido Kroemer (eds.)Oncoimmunologyhttps://doi.org/10.1007/978-3-319-62431-0_43 43. Concluding Remarks Pedro Romero1 and Wolf H. Fridman1 (1) Ludwig Cancer Research Center at University of Lausanne, Switzerland and Cordeliers Research Center, Paris, France …
Immunotherapy of Gliomas
Fig. 39.1 A workflow of immunotherapy discovery and combinatorial treatment approaches in neurooncology References 1. Ousman SS, Kubes P. Immune surveillance in the central nervous system. Nat Neurosci. 2012;15:1096–101.CrossrefPubMed 2….
Melanoma: Immunotherapy in Advanced Melanoma and in the Adjuvant Setting
Advanced melanoma Outcome Publication (Ref) gp100 vs ipilimumab vs ipilimumab + gp100 Ipilimumab 3 mg/kg approved OS benefit Hodi et al. [18] DTIC vs DTIC + ipilimumab Ipilimumab 10 mg…
Peptide-Based Therapeutic Cancer Vaccines
Fig. 14.1 Mode of action of synthetic long peptide vaccination. The tumor-associated antigens are efficiently delivered by SLP easily obtaining access to DC in the vaccine injection area. Antigen-loaded DC…
The Impact of the Intestinal Microbiota in Therapeutic Responses Against Cancer
Fig. 27.1 The immunogenicity of E. hirae. E. hirae resides in the jejunum and colon in about 25% individuals. It is very dominant in mouse guts at Gustave Roussy Villejuif….
Purinergic Receptors: Novel Targets for Cancer Immunotherapy
Fig. 7.1 Generation of extracellular ATP and adenosine in the tumor microenvironment (TME). (1) In response to hypoxia, cells in the TME release ATP through either ATP-binding casettes, Pannexin-1 or…
Co-stimulation Agonists via CD137, OX40, GITR, and CD27 for Immunotherapy of Cancer
Fig. 26.1 Constitutive and activation-induced co-stimulatory members of the TNF and TNFR families expressed on T cells, NK cells, and antigen-presenting cells (APCs). Schematic representation of an immune synapse between…
Innate Immune Receptors in the Regulation of Tumor Immunity
© Springer International Publishing AG 2018Laurence Zitvogel and Guido Kroemer (eds.)Oncoimmunologyhttps://doi.org/10.1007/978-3-319-62431-0_25 25. Innate Immune Receptors in the Regulation of Tumor Immunity Sho Hangai1, 2, Yoshitaka Kimura1, 2, Tadatsugu Taniguchi1, 2 and Hideyuki Yanai1, 2 (1) Department of Molecular Immunology,…
