and Hypofractionation for Primary Tumors
Fig. 1 External compression was one of the first techniques used to address tumor motion in lung SBRT Fig. 2 Image guidance with CBCT prior to delivery was sufficient to provide treatment…
Mammalian DNA Damage Response as a Target for Therapeutic Gain in Radiation Oncology
© Springer International Publishing AG 2017Jeffrey Y.C. Wong, Timothy E. Schultheiss and Eric H. Radany (eds.)Advances in Radiation OncologyCancer Treatment and Research10.1007/978-3-319-53235-6_11 The Mammalian DNA Damage Response as a Target for Therapeutic Gain in Radiation…
and Radiotherapy
© Springer International Publishing AG 2017Jeffrey Y.C. Wong, Timothy E. Schultheiss and Eric H. Radany (eds.)Advances in Radiation OncologyCancer Treatment and Research10.1007/978-3-319-53235-6_10 Biomarkers and Radiotherapy Savita V. Dandapani1 (1) Department of Radiation Oncology, City of Hope, Duarte,…
and the Treatment of Oligometastatic Disease
Publication Year Number of patients Median follow-up (months) RT dose Metastases control Overall survival University of Chicago (Wong et al. 2016) 2016 61 82 24–48 Gy in 3 fractions 44% at…
Impact of IGRT on Normal Tissue Toxicity
. where P(D, 1) is the probability of a lesion occurring if the entire organ is irradiated to dose D. This formula was derived using the simple notion that the…
Radiotherapy and Immunotherapy
Fig. 1 Ideally, drug combinations should shift the balance between the pro-immunogenic and immunosuppressive effects of radiotherapy to favor its pro-immunogenic effects and or abrogate the immune-suppressive ones. Multiple strategies in…
Hematopoietic Stem Cells: The Basis of Normal and Malignant Hematopoiesis
Fig. 1.1 Site of hematopoiesis during fetal development. Hematopoietic stem cells (HSCs) are thought to derive from the ventral mesoderm. The initial blood production termed as “primitive hematopoiesis” occurs in…
Primary Hemophagocytic Lymphohistiocytosis
Disease Defective gene Protein Inheritance Protein function FHL syndromes without hypopigmentation FHL2 PRF1 Perforin AR Pore formation FHL3 UNC13D Munc13-4 AR Vesicle priming FHL4 STX11 Syntaxin11 AR Vesicle fusion FHL5…
Myelodysplastic Syndrome (MDS) and Juvenile Myelomonocytic Leukemia (JMML)
Fig. 4.1 Distribution of patients with myelodysplastic syndrome, myeloproliferative neoplasms, and bone marrow failure in Japan (Reference [3]). One thousand patients were prospectively underwent the central review of morphology and…
Acute Lymphoblastic Leukemia
Study group Trial Years ALL subtypes No. of patients Age EFS, % (year) OS, % (year) Reference AIEOP/BFM AIEOP-BFM ALL 2000 2000–2006 B-ALL 4016 1–18 80.4 (7) 91.8 (7) Conter…
