Artificial thrombocytopenia Platelet aggregation caused by insufficient anticoagulation Platelet aggregation caused by EDTA-dependent immunoglobulin (pseudothrombocytopenia) Giant platelets Decreased platelet production Congenital thrombocytopenia MYH9-related macrothrombocytopenia Wiskott-Aldrich syndrome Congenital amegakaryocytic thrombocytopenia (CAMT),…
Newly diagnosed ITP Resolution within 3 months of diagnosis Persistent ITP Resolution 3–12 months from diagnosis; includes patients not reaching spontaneous remission or not maintaining complete response off therapy Chronic…
International consensus report ASH BSCH Japan First-line Prednisone/prednisolone (10–20 mg/day) IVIG (dose not specified) IV anti-D Prednisone/prednisolone (1 mg/kg/day) IVIG (1 g/kg for 2 days) Prednisone/prednisolone (1 mg/kg/day) IVIG…
© Springer Nature Singapore Pte Ltd. 2017Yoji Ishida and Yoshiaki Tomiyama (eds.)Autoimmune Thrombocytopenia 10.1007/978-981-10-4142-6_18 Others (Syk Inhibitor and Other Medications) Yoji Ishida1 (1) Division of Hematology and Oncology, Department of Internal Medicine, Iwate Medical University School…
Bleeding risk Reference Fever (38.5 °C<) [13] Infection [13] Anticoagulant drugs [14] Amphotericin use [10, 15] Hypoalbuminemia [16] Uremia [16] Recent bleeding episodes [16] Recent bone marrow transplantation [16] Acute…
Fig. 1 Structure and binding site of romiplostim and eltrombopag. Upper panel: romiplostim is a “peptibody” and TPO receptor-binding domain consists of 14 amino acids (Ile-Glu-Gly-Pro-Thr-Leu-Arg-Gln-Trp-Leu-Ala-Ala-Arg-Ala), and eltrombopag is a…
© Springer Nature Singapore Pte Ltd. 2017Yoji Ishida and Yoshiaki Tomiyama (eds.)Autoimmune Thrombocytopenia 10.1007/978-981-10-4142-6_14 High-Dose Immunoglobulin Tatsuo Oyake1 and Yoji Ishida1 (1) Division of Hematology and Oncology, Department of Internal Medicine, Iwate Medical University School of Medicine,…
© Springer Nature Singapore Pte Ltd. 2017Yoji Ishida and Yoshiaki Tomiyama (eds.)Autoimmune Thrombocytopenia 10.1007/978-981-10-4142-6_15 Splenectomy Shugo Kowata1 and Yoji Ishida1 (1) Division of Hematology and Oncology, Department of Internal Medicine, Iwate Medical University School of Medicine, Morioka,…
© Springer Nature Singapore Pte Ltd. 2017Yoji Ishida and Yoshiaki Tomiyama (eds.)Autoimmune Thrombocytopenia 10.1007/978-981-10-4142-6_13 Steroids Toshiro Takafuta1 and Kingo Fujimura2 (1) Department of Clinical Research, Hiroshima-Nishi Medical Center, Hiroshima, Japan (2) Department of Nursing, Yasuda Women’s University,…
