Randomized Clinical Trials in Rectal and Anal Cancers
This article reviews randomized clinical trials (RCTs) published between April 2001 and November 2008 on the management of patients with rectal cancer. In total, the authors reviewed 78 RCTs on…
Randomized Clinical Trials in Colon Cancer
Surgery remains the mainstay of treatment for colon cancer and surgical resection alone results in 5-year survival in more than 60% of patients. However, the use of fluorouracil (5-FU)-based adjuvant…
An Update on Randomized Clinical Trials in Advanced and Metastatic Colorectal Carcinoma
During the past eight years, there have been significant advances in the treatment and outcome of patients with metastatic colorectal cancer. This is likely the result of improved imaging, staging,…
Randomized Clinical Trials in Hepatocellular Carcinoma
Hepatocellular carcinoma is among the most common solid tumors, ranking behind only lung and gastric for cancer-related deaths worldwide. Despite improved surveillance programs in many countries, most patients present with…
Randomized Clinical Trials in Pancreatic Adenocarcinoma
This article critically reviews and ranks 107 prospective, randomized controlled trials (RCT) for pancreatic adenocarcinoma published between 2000 and 2008 identified through a standard MEDLINE literature search strategy, according to…
Randomized Clinical Trials in Gastrointestinal Stromal Tumors
Gastrointestinal (GI) stromal tumor (GIST) is the most common mesenchymal tumor of the GI tract, constituting 80% of all GI mesenchymal tumors and approximately 20% of all small bowel malignancies,…
Randomized Clinical Trials in Gastric Cancer
Minimally invasive resection has emerged as a surgical technique for gastric cancer, and there has been continued investigation to determine the appropriate extent of lymphadenectomy in gastric cancer patients. There…
Randomized Clinical Trials in Esophageal Carcinoma
The treatment of esophageal cancer with curative intent remains highly controversial, with advocates of surgery alone, chemoradiotherapy alone, surgery with adjuvant therapy (including neoadjuvant and postoperative), and trimodality therapy each…
Randomized Clinical Trials in Breast Cancer
Breast cancer remains the most common cancer diagnosed in women and the second leading cause of cancer-related deaths in this group. Significant advances in the treatment of breast cancer and…
Randomized Clinical Trials in Melanoma
The incidence of melanoma is increasing and it is estimated that, in the United States, the lifetime risk of developing melanoma is 1 in 55. There have been many randomized…
