Cervical Cancer PDOX Models
Fig. 10.1 Drug-efficacy testing in the PDOX model. PDOX nude mice were treated with saline, carboplatin, trastuzumab + lapatinib, trastuzumab + lapatinib + entinostat, or entinostat alone. (a) Bar graphs…
In Memoriam: Jørgen Rygaard (1934–2016), Father of Patient-Derived Mouse Models of Cancer and Modern Cancer Research
The athymic “nude” mouse is possibly the most important tool in cancer research. The nude mouse has enabled the studies of human cancer in the laboratory in vivo. Nude mice…
The First Patient-Derived Orthotopic Xenograft (PDOX) Mouse Models of Cancer: Cancer of the Colon, Pancreas, Lung, Breast, Ovary, and Mesothelioma
© Springer International Publishing AG 2017Robert M. Hoffman (ed.)Patient-Derived Mouse Models of Cancer Molecular and Translational Medicinehttps://doi.org/10.1007/978-3-319-57424-0_7 7. The First Patient-Derived Orthotopic Xenograft (PDOX) Mouse Models of Cancer: Cancer of the Colon, Pancreas, Lung,…
Techniques for Surgical Orthotopic Implantation of Human Tumors to Immunodeficient Mice
© Springer International Publishing AG 2017Robert M. Hoffman (ed.)Patient-Derived Mouse Models of Cancer Molecular and Translational Medicinehttps://doi.org/10.1007/978-3-319-57424-0_6 6. Techniques for Surgical Orthotopic Implantation of Human Tumors to Immunodeficient Mice Robert M. Hoffman1, 2 (1) AntiCancer, Inc.,…
The Role of the JAK/STAT Signalling Pathway in Immunoregulation of Gastrointestinal Cancers
Fig. 7.1 The JAK-STAT signalling pathway. Upon binding to the membrane receptors, cytokines initiate downstream signalling cascades through the JAK-STAT pathway. Cytokine receptor homodimers or heterodimers phosphorylate and activate JAKs,…
Hypermutated Colorectal Cancer and Neoantigen Load
Fig. 8.1 DNA mismatch errors commonly occur at unstable genomic regions with multisatellite repeats. The repair of such DNA mismatch errors is the function of the MMR system. This process…
Therapeutic Cancer Vaccines
Fig. 3.1 Cancer vaccination and induction of T cell activation Vaccine Platforms and Vectors Common Mechanisms of Action This section will discuss various therapeutic cancer vaccine constructs, including peptide, DNA,…
PD1 and PD-L1 Immune Checkpoint Inhibitors in Gastrointestinal Cancer
Phase Regimen Patient population Results I Pembrolizumab (anti-PD-1 antibody) Advanced solid tumours, including oesophageal cancer ORR: 30.4 % (29.4 % in squamous cell carcinoma vs. 40 % in adenocarcinoma); 12-month…
Let’s Talk About Stress
• A review of 165 studies found that stress-related psychosocial factors are associated with higher cancer incidence in initially healthy populations, poorer survival in patients diagnosed with cancer (330 studies),…
