© Springer International Publishing AG 2017Yuzhuo Wang, Dong Lin and Peter W. Gout (eds.)Patient-Derived Xenograft Models of Human Cancer Molecular and Translational Medicine10.1007/978-3-319-55825-7_1 1. Patient-Derived Tumor Xenografts: Historical Background Dong Lin1, 2, 3 , Xinya Wang1, Peter W. Gout4, 3 and…
Fig. 2.1 Overview of the main steps in establishing PDXs. Step 1: High-quality patient specimens are obtained from various stages of cancer progression, from benign tissue to metastases, using a…
Fig. 5.1 Efficacy study of S-1 in four gastric PDX models. a and b show that GAPF155 and GAPF157 were sensitive to S-1; c and d show that GAPF161 and…
Fig. 4.1 Overturning the aspiration needle and tapping the material on the slide can often facilitate removal of partially clotted specimen in the needle hub Once a small amount of…
Fig. 13.1 (a) Lymph node groups in the neck. From Fialkowski EA, Moley JF. Current approaches to medullary thyroid carcinoma, sporadic, and familial. (b) Specimen from a patient following central…
Fig. 19.1 A 40-year-old female with papillary thyroid carcinoma and positive nodal metastases on dissection. TBI (a) with SPECT (b) showing uptake in the neck, which localizes to the thyroid…
Fig. 9.1 Ultrasound, right transverse Fig. 9.2 Ultrasound, lymph node Fig. 9.3 CT showing right thyroid mass Fig. 9.4 CT He underwent a total thyroidectomy, central neck dissection, and right…
Fig. 17.1 Size distribution of maximal tumor diameter in 4138 adult PTC patients consecutively treated at Mayo during 1935–2014 and demonstrating that one-third of these patients during the eight decades…
Surveillance method Description Advantages/benefits Disadvantages/limitations Thyroglobulin (Tg) Protein product of thyroid follicular cells Most sensitive method for detecting the presence of disease, particularly after stimulation with rhTSH or THW Wide…
External Beam Radiotherapy External beam radiotherapy is a useful option in advanced DTC, particularly when the disease is iodine nonavid. It is most commonly used to treat surgically unresectable locoregional…
