Thrombotic Microangiopathies

Jun 23, 2017 by in HEMATOLOGY Comments Off on Thrombotic Microangiopathies

Ruutu T, Barosi G, Benjamin RJ, Clark RE, George JN, Gratwohl A, et al. European Group for Blood and Marrow Transplantation; European LeukemiaNet. Diagnostic criteria for hematopoietic stem cell transplant-associated microangiopathy:…

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Endocrine Complications in Childhood Cancer Survivors

Jun 23, 2017 by in HEMATOLOGY Comments Off on Endocrine Complications in Childhood Cancer Survivors

Alkylating agents Busulfan Cisplatin Cyclophosphamide Ifosfamide Mechlorethamine Melphalan Nitrosureas BCNU (carmustine) CCNU (lomustine) Procarbazine Thiotepa Primary factors associated with late endocrine complications are as follows: 1. Radiotherapy: the involved field,…

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Kidney Disease in Hematopoietic Stem Cell Transplantation

Jun 23, 2017 by in HEMATOLOGY Comments Off on Kidney Disease in Hematopoietic Stem Cell Transplantation

(1) Portland Veterans Administration Medical Center, Oregon Health & Science University, 3710 SW US Veterans Hospital Road, P3NEPH, 97239 Portland, OR, USA   KeywordsAcute kidney injuryChronic kidney diseaseChronic kidney disease in…

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Cardiovascular Complications

Jun 23, 2017 by in HEMATOLOGY Comments Off on Cardiovascular Complications

Fig. 23.1 Standard approaches to acute atrial fibrillation   b. Rate controlling agents (all can cause hypotension and bradycardia and should be administered in a monitored setting) i. Metoprolol 5 mg…

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Oral Complications

Jun 23, 2017 by in HEMATOLOGY Comments Off on Oral Complications

Grade WHOa NCI-CTCb Bearman Grade 0 No oral abnormalities No oral abnormalities No oral abnormalities Grade 1 Oral soreness +/− erythema without ulceration; able to tolerate regular diet Erythema Pain…

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Gastrointestinal Complications

Jun 23, 2017 by in HEMATOLOGY Comments Off on Gastrointestinal Complications

Grade Diarrhea 1 Increase of < 4 stools per day over baseline; mild increase in ostomy output compared to baseline 2 Increase of 4–6 stools per day over baseline; IV fluid…

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Chronic Graft-Versus-Host Disease

Jun 23, 2017 by in HEMATOLOGY Comments Off on Chronic Graft-Versus-Host Disease

Organ or site Diagnostic (adequate for the diagnosis of cGvHD) Distinctive (seen in cGvHD but not aGvHD; insufficient to establish cGvHD diagnosis) Other features (cannot be used to establish a…

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Follow-Up Care

Jun 23, 2017 by in HEMATOLOGY Comments Off on Follow-Up Care

– Day 100 evaluation Additional evaluation Aplastic anemia Bone marrow biopsy/aspirate for path, flow, and FISH for MDS panel EBV titers monthly posttransplant × 12 months – Chimerismsa – – CBC…

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Engraftment

Jun 23, 2017 by in HEMATOLOGY Comments Off on Engraftment

Major criteria Minor criteria T ≥ 38.3 °C with no identifiable infectious etiology Hepatic dysfunction with either total bilirubin ≥ 2 mg/dL or transaminase levels ≥ 2x ULN Erythrodermatous rash involving > 25 % BSA and not…

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