Multidisciplinary Approach of Prostate Cancer Patients
Rationale and definition of MDT Promotion of MDT considered as an ethical priority, given the benefits of MDT and the imperative to provide all patients with the best possible care…
Economic Impact of Prostate Cancer Bone Metastases
Skeletal-related event Mean cost per skeletal-related event (€) Germany Italy Spain UK Non-vertebral fracture 1,720 2,087 3,209 2254 Vertebral fracture 2,124 2,142 6,968 1,015 Radiation to bone 1,694 2,461 2,378…
Biology and Pathophysiology of Bone Metastasis in Prostate Cancer
Fig. 1.1 Histopathology of bone metastasis (BMT) from prostate cancer (PC). In the same patient, BMTs are heterogeneous, with predominantly blastic (1) and predominantly lytic metastases (2). Furthermore, as shown…
New Frontiers in Treatment
© Springer International Publishing Switzerland 2017Francesco Bertoldo, Francesco Boccardo, Emilio Bombardieri, Laura Evangelista and Riccardo Valdagni (eds.)Bone Metastases from Prostate Cancer 10.1007/978-3-319-42327-2_17 17. New Frontiers in Treatment Sergio Bracarda1 , Alketa Hamzaj1 and Kalliopi Andrikou1 (1) Medical Oncology, Department of Oncology Azienda…
Bone-Seeking Radionuclide for Therapy
Type of decay Particle/photon Relative mass (AMU) Charge Typical LET (kV/μm) Alpha Helium nucleus 4 +2 60–300 Beta Electron (or positron) 1/2000 −1 electron (+1 positron) 0.1–1 Gamma Photon 0…
Combinations of Hormonal Therapy and Chemotherapy
Fig. 12.1 Representation of two models of development of castration-resistant prostate cancer (CRPC) from castration-sensitive prostate cancer (CSPC). ADT androgen deprivation therapy. Androgen-dependent prostate cancer cells are represented in blue,…
Chemotherapy
© Springer International Publishing Switzerland 2017Francesco Bertoldo, Francesco Boccardo, Emilio Bombardieri, Laura Evangelista and Riccardo Valdagni (eds.)Bone Metastases from Prostate Cancer 10.1007/978-3-319-42327-2_11 11. Chemotherapy Giovanni Luca Ceresoli1 , Maria Bonomi1 and Maria Grazia Sauta1 (1) Department of Medical Oncology, Cliniche Humanitas Gavazzeni, Bergamo, Italy…
Markers of Prostate Cancer: The Role of Circulating Tumor Markers in the Management of Bone Metastases
Clinical question No. of tools concerning the clinical question No. of tool that considered PSA No. of tools subjected to validation Prediction of the presence of prostate cancer in the…
Circulating Tumor Cells (CTCs) and Metastatic Prostate Cancer (mPCa)
Fig. 5.1 In this picture, it is possible to see CTCs with different morphology detected with CellSearch platform. CTCs are immune-magnetically enriched with a specific antibody for epithelial cell adhesion…
Neurological Complications
and Paul Telfer2 (1) Department of Haematology, Guy’s and St Thomas’ Hospital, London, UK (2) Department of Haematology, Royal London Hospital, London, UK Introduction The brain is particularly vulnerable to…
