Multiple Myeloma
Kenneth C. Anderson, MD, Editor Remarkable progress has been achieved in our understanding of the biology and pathogenesis of multiple myeloma in its bone marrow microenvironment. Novel agents, including immunomodulatory…
Referral to Transplant Center for Hematopoietic Cell Transplantation
Hematopoietic cell transplantation is a complex and highly specialized medical procedure offered by selected centers with the requisite expertise and resources. Timely referral to a transplant center is among the…
Hematopoietic Stem Cell Transplantation for Primary Immunodeficiencies
Allogeneic hematopoietic stem cell transplantation has been shown to be curative for well-described as well as newly discovered immunodeficiencies. However, it is difficulty to define a universal transplant regimen given…
Bone Marrow Transplantation for Acquired Severe Aplastic Anemia
This article addresses current transplant options for patients with acquired severe aplastic anemia (SAA). This discussion includes ongoing progress in the use of SAA in the setting of unrelated donor…
Allogeneic Stem Cell Transplantation for Thalassemia Major
Allogeneic stem cell transplant remains the only curative option for β-thalassemia major. In patients with good risk features it is reasonable to anticipate a greater than 90% chance of a…
Hematopoietic Stem Cell Transplantation for Patients with Sickle Cell Disease
Research has solidified matched sibling marrow, cord blood, or mobilized peripheral blood as the best source for allogeneic hematopoietic stem cell transplantation for patients with sickle cell disease, with low…
Multiple Myeloma
Autologous stem cell transplant (ASCT) remains an integral part of the treatment strategy for many myeloma patients. The role of allogeneic stem cell transplant continues to be defined. There is…
High Dose Melphalan and Autologous Peripheral Blood Stem Cell Transplantation in AL Amyloidosis
AL amyloidosis is the most common form of systemic amyloidosis and is associated with an underlying plasma cell dyscrasia. It is often difficult to recognize because of its many manifestations….
Stem Cell Transplantation in Hodgkin Lymphoma
Patients with Hodgkin lymphoma (HL) who relapse following effective front-line therapy are offered salvage second-line chemotherapy regimens followed by high-dose therapy and autologous stem cell transplantation (HDT/ASCT). Randomized studies comparing…
Hematopoietic Stem Cell Transplantation for Non-Hodgkin Lymphoma
Up-front rituximab-based chemotherapy has improved outcomes in non-Hodgkin lymphoma (NHL); refractory or relapsed NHL still accounts for approximately 18,000 deaths in the United States. Autologous hematopoietic stem cell transplantation (SCT)…
