Evidence-Based Therapeutic Approaches for mCRPC Patients: Rational Sequence of Standard Treatment Options and Design for Future Drug Development

Mar 13, 2017 by in ONCOLOGY Comments Off on Evidence-Based Therapeutic Approaches for mCRPC Patients: Rational Sequence of Standard Treatment Options and Design for Future Drug Development

© Springer Science+Business Media New York 2014Fred Saad and Mario A. Eisenberger (eds.)Management of Castration Resistant Prostate CancerCurrent Clinical Urology10.1007/978-1-4939-1176-9_23 23. Evidence-Based Therapeutic Approaches for mCRPC Patients: Rational Sequence of Standard Treatment Options and Design…

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Defining Clinical Endpoints in Castration-Resistant Prostate Cancer

Mar 13, 2017 by in ONCOLOGY Comments Off on Defining Clinical Endpoints in Castration-Resistant Prostate Cancer

© Springer Science+Business Media New York 2014Fred Saad and Mario A. Eisenberger (eds.)Management of Castration Resistant Prostate CancerCurrent Clinical Urology10.1007/978-1-4939-1176-9_14 14. Defining Clinical Endpoints in Castration-Resistant Prostate Cancer Jorge A. Garcia1, 2   and Robert Dreicer1, 2 (1) Department…

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Introduction

Mar 13, 2017 by in ONCOLOGY Comments Off on Introduction

Targeted treatment combined with docetaxel Phase I docetaxel combination trial in CRPC, N Any unexpected safety signals? Pharmacodynamic studies Phase II docetaxel-combination trial in CRPC design (N) Statistical plan Primary…

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Targeting C-Met/VEGF in Castration Resistant Prostate Cancer

Mar 13, 2017 by in ONCOLOGY Comments Off on Targeting C-Met/VEGF in Castration Resistant Prostate Cancer

Fig. 19.1 Schematic examples of HGF/MET and/or VEGF/VEGFR inhibitors mechanism of action. VEGFR vascular endothelial growth factor receptor, PDGFR platelet-derived growth factor receptor, HGF hepatocyte growth factor, FLT3 FMS-like tyrosine…

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Angiogenesis Inhibition in Castration-Resistant Prostate Cancer

Mar 13, 2017 by in ONCOLOGY Comments Off on Angiogenesis Inhibition in Castration-Resistant Prostate Cancer

Fig. 15.1 TGF-β transforming growth factor-β; HGF hepatocyte growth factor; VEGF vascular endothelial growth factor; PLGF placental growth factor; Ang angiopoietin; PDGF platelet-derived growth factor; FGF fibroblast growth factor Although…

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Molecular Mechanisms of Prostate Cancer Progression After Castration

Mar 13, 2017 by in ONCOLOGY Comments Off on Molecular Mechanisms of Prostate Cancer Progression After Castration

Phenotype Molecular basis Mechanism Consequence AR-addicted Adrenal or intra-tumoral androgen biosynthesis Androgens produced sufficient to activate AR Responds to androgen biosynthesis inhibitors and selected AR antagonists AR mutation Alters ligand…

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Bone-Targeted Therapy: Rationale and Current Status

Mar 13, 2017 by in ONCOLOGY Comments Off on Bone-Targeted Therapy: Rationale and Current Status

Fig. 10.1 The vicious cycle of bone metastases Transforming growth factor beta (TGFβ) is released from resorbed bone matrix and has been shown to augment signaling through parathyroid hormone-related protein…

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