Phosphatidylinositol 3-Kinase Pathway
(1) Institut Bergonié, Bordeaux, France Abstract The phosphatidylinositol 3-kinase (PI3K) pathway is one of the signalling pathways activated following the interaction of a growth factor with a tyrosine kinase…
Growth Factors and Tyrosine Kinase Receptors
(1) Institut Bergonié, Bordeaux, France Abstract Signalling pathways originating from the interaction between growth factors (GF) and tyrosine kinase receptors (TKRs) are certainly the best known because of their…
Toll-Like Receptors, Interleukin 1 and NFκB
(1) Institut Bergonié, Bordeaux, France Abstract Toll-like receptors (TLR) constitute a family of receptors involved in immune and inflammatory processes, which recognise molecules derived from infectious agents (bacteria, viruses)…
G-Protein-Coupled Receptors
(1) Institut Bergonié, Bordeaux, France Abstract G-protein-coupled receptors (GPCRs) constitute a huge family of membrane receptors to numerous hormones, neurotransmitters and diverse compounds. A large part of cardiovascular and…
Nuclear Receptor Pathways
(1) Institut Bergonié, Bordeaux, France Abstract Nuclear receptors constitute a special class of transcription factors that are activated by an extracellular signal. This signal is a hydrophobic substance, such…
MAP Kinase Pathway
(1) Institut Bergonié, Bordeaux, France Abstract The MAP kinase pathway (or, better, the MAP kinase pathways) is certainly one of the main proliferation pathways, the best known and the…
Lymphocyte Receptor Pathways
(1) Institut Bergonié, Bordeaux, France Abstract The two types of lymphocytes, B and T, which are, respectively, responsible for humoral and cell-mediated immunity, express membrane receptors in relation to…
Ion Channel-Coupled Receptors
(1) Institut Bergonié, Bordeaux, France Abstract Conduction of nerve impulse is a major signalling pathway in multicellular organisms and requires ion channels situated at the level of plasma membranes…
Semaphorins and Adhesion Molecules
(1) Institut Bergonié, Bordeaux, France Abstract Semaphorins constitute a group of signalling proteins originally described in the central nervous system where they are involved in the growth of the…
