Fig. 11.1 The peritoneal cancer index uses the distribution of cancer implants throughout the abdomen and pelvis combined with a lesion size of these nodules in order to quantitate the…
Stage I: Growth limited to the ovaries IA: Tumour limited to one ovary; capsule intact, no tumour on ovarian surface; no malignant cells in ascites or peritoneal washings IIB: Tumour…
Fig. 14.1 Conceptual model of QOL in ovarian cancer (Adapted from Kornblith et al. [2] and [3]) As recognition of the importance of QOL as a patient-centered outcome has increased…
Fig. 12.1 Mediators of tumor angiogenesis Antiangiogenic Agents Bevacizumab Bevacizumab is a recombinant, humanized, monoclonal immunoglobulin G1 antibody targeted at VEGF-A, which is approved for the treatment of metastatic colorectal…
Fig. 8.1 Distribution of tumor histopathology shown as a percentage of total ovarian tumors in SEER database study (From Brookfield et al. [4]; with permission) Table 8.1 Histologic classification of…
Biomarker Description Method Reference CA 15-3 Tumor antigen Serum ELISA Woolas et al. [41] CA 19-9 Tumor antigen Serum ELISA Woolas et al. [41] TAG-72 Tumor antigen Serum ELISA Woolas…
Professional group Recommendation US Preventive Services Task Force Does not recommend routine screening, concluding that “the potential harms outweigh the potential benefits” American Cancer Society Does not recommend routine screening;…
Level of evidence Factor Most frequently observed observation Strong Age Younger age—more distress Disease stage More advanced disease—more distress Time since diagnosis Shorter—more distress Disability status Worse—more distress Physical symptoms…
Established risk factors Possible risk factors Suspected risk factors Age Early age at menarche Hormonal replacement therapy Family history – genetics Late age at menopause Dietary fat Nulliparity Infertility Obesity…
Syndrome Manifestations Inheritance Gene(s) Reference Hereditary breast and ovarian cancer Early-onset breast or ovarian cancer, multiple primary cancers, cancer in several generations, male breast cancer AD BRCA1 [19] BRCA2 [20]…
