Fig. 7.1 Five-year cumulative incidence of HCC in different etiologies of liver cirrhosis (Data from Fattovich et al., Gastroenterology 2004;127:S35-50) Obviously, structural and functional abnormalities pertinent to alcoholic cirrhotic transformation…
Fig. 12.1 Alcohol and HCV in liver disease: common sites of action 12.2 Alcohol, HCV and Innate Immunity The immune response is a common target of both alcohol and the…
Fig. 21.1 Tumor incidence in two models of HCC and EtOH consumption. (a) Twenty-one-day-old male C57BL/6 or B6C3 mice were injected with vehicle (Veh; 100 μL sterile olive oil) or…
Fig. 17.1 CEA processing and metastatic potential of colorectal cancer cells (CRC) in the alcohol-injured liver. (a) The potential effects of alcohol on the direct processing of CEA by Kupffer…
Fig. 5.1 The reaction of acetaldehyde with deoxyguanosine results in the formation of N2-ethylidendene-dG; this unstable Schiff base can be converted through a reduction step to the more stable form:…
Reference Gender Age FASD Cancer type [7] M 28 months Yes Neuroblastoma [11] F 3 years 9 months Yes, with hydantoin Hodgkin disease [33] F 12years 11 months Yes Adrenal…
Group Tumor foci Adenoma % Incidence Multiplicity % Incidence Multiplicity Chow + DEN (n = 17) 16/17 = 94 100/17 = 5.8a 1/17 = 6 2/17 = 0.1a PF + DEN (n = 18) 18/18 = 100* 209/18 = 11.6b 10/18 = 55* 15/18 = 0.8b EtOH + DEN (n = 15) 16/15 = 100* 266/15 = 17.7c 9/15 = 60* 33/15 = 2.2c % Incidence = number…
Fig. 16.1 ALDHs modulate carcinogenesis by metabolizing acetaldehyde and retinaldehyde. Ethanol is metabolized by alcohol dehydrogenase (ADH), catalase, and CYP2E1 to acetaldehyde. Acetaldehyde can interfere with antioxidative defense systems (AODS)…
Fig. 20.1 Hematopoiesis. The current model of hematopoiesis is depicted below. In this model hematopoietic cells are derived from a small number of HSCs that progress through a series of…
Fig. 15.1 Phenotypes of the alcohol dehydrogenase-1B*1/*1 (ADH1B*1/*1) and aldehyde dehydrogenase-2*1/*2 (ALDH2*1/*2) genotypes and their relationships to ethanol and acetaldehyde exposure and accumulation 15.3 ALDH2 Genotype and Squamous Cell Neoplasia…
