Recommendation Level of evidencea Insertion Hand hygiene with soap and water or waterless alcohol gel 1A Maximal sterile barrier precautions: cap, mask, sterile gown, sterile gloves, sterile full body…
Therapy-related risk factors Chemotherapy and biotherapy agents Antimetabolites Cytarabine 5-fluorouracil Methotrexate Antitumor antibiotics Actinomycin D Amsacrine Mithramycin Mitomycin Alkylating agents Busulfan Cyclophosphamide Mechlorethamine Procarbazine Thiotepa Anthracyclines Daunorubicin Doxorubicin Epirubicin Taxanes…
Fig. 9.1 Pain assessment tools. (a) FLACC behavioral pain assessment scale. (b) Wong-Baker faces pain scale. (c) Visual analog scale (VAS) The perception of pain is directly related to a…
Clinical scenario Recommendations Level of evidenceb Spinal cord compression Corticosteroids: decadron 1–2 mg/kg (max 10 mg) followed by 0.25–0.5 mg/kg (max 4 mg) Q6h—may complicate ability to make a diagnosis…
Clinical scenario Recommendation Level of evidencea Risk stratification Must be individualized at local institutions due to lack of evidence to support the needs of each individual treatment area 2C Baseline…
© Springer Berlin Heidelberg 2015James H. Feusner, Caroline A. Hastings and Anurag K. Agrawal (eds.)Supportive Care in Pediatric OncologyPediatric Oncology10.1007/978-3-662-44317-0_18 18. Knowledge Gaps and Opportunities for Research Anurag K. Agrawal1 , Caroline A. Hastings1 and James H. Feusner1 (1) Department of Hematology/Oncology, Children’s…
Prior to chemotherapyb During chemotherapyc After chemotherapy completionc, d Diphtheria-tetanus-acellular pertussis Continuation of primary series during lower-intensity phases of therapy (i.e., ALL in maintenance) Continuation of primary series; booster…
Clinical scenario Recommendation Level of evidenceb Treatment of myelosuppression after chemotherapy (primary prophylaxis) Consider if risk of neutropenia is ≥20 % or if patient had neutropenia with previous course of…
Recommendation Grade Comments Reference Data from studies of non-oncology patientsa Data from studies of adult oncology patientsa Data from studies of pediatric oncology patientsa Antibacterial prophylaxis with a fluoroquinolone should…
Clinical scenario Recommendations Level of evidencea SVCS/SMS Elevate head of the bed 1C Place all IV lines in lower extremities 2C Consider use of loop diuretics 2C Remove indwelling catheter…
