de Quervain
Fritz de Quervain, MD Fritz de Quervain is regarded as one of the last surgical giants, and his obituary appeared in Nature after his death on January 24, 1940 [1]….
and Thyroiditis
Nervousness Heat intolerance Insomnia Anxiety Hyperhidrosis Weight loss Fatigue Muscle weakness Decreased menstrual flow Palpitations Signs Tachycardia Ophthalmopathy Dermopathy (pretibial myxedema) Proximal muscle weakness Diffuse goiter (+ /- bruit) Fine…
James Graves
Robert James Graves. (Etching by Sherman & Smith. Image from the History of Medicine (NLM)) As a lecturer Professor Graves was endowed with peculiar capabilities. To a remarkable person he…
Post-transcriptional Regulation of Luteinizing Hormone Receptor mRNA Expression in the Ovary
Fig. 4.1 LHR mRNA levels during hCG-induced downregulation. Northern blot analysis of steady state LHR mRNA levels in total RNA, isolated at the indicated times, from the ovaries of saline-injected…
Post-transcriptional Regulation of Glucocorticoid Function
Fig. 13.1 Mechanisms of GC action discussed in this review. GCs exert their anti-inflammatory action through multiple mechanisms mediating coordinate changes in gene expression (see text). Regulation of inflammatory responses…
Mechanisms of Post-transcriptional Gene Regulation
Fig. 1.1 Translation initiation and common mechanisms of regulation. The steps of translation initiation are outlined in (a). The ternary complex is comprised of eIFs 1, 1A, 3 and 5…
Post-transcriptional Regulation of Parathyroid Hormone Gene Expression in Health and Disease
Fig. 11.1 Calcium , phosphate , PTH, FGF23, 1,25D and FGF23 interactions. There are endocrinological feedback loops that govern mineral homeostasis. FGF23, fibroblast growth factor 23; PTH, parathyroid hormone ,…
Post-transcriptional Regulation of Insulin and Insulin Like Growth Factors
Fig. 2.1 Schematic representation of the human insulin (a) and mouse insulin 2 (b) genes. The both genes consist of three exons (boxes), and two introns (lines). The coding region…
Post-transcriptional Regulation of Steroid Hormone Receptors
Gene name 3′UTR miR sites References NR3A1/ESR1 4307 b Let-7 Manavathi et al. (2013) miR-137 Zhao et al. (2008) Zhao et al. (2008) Zhao et al. (2008) miR-145 miR-17-5p miR-18a/19b/20b…
Post-transcriptional Regulation of Prostaglandin Biosynthesis
Fig. 9.1 Overview of the PGE2 synthesis pathway. Arachidonic acid is liberated from phospholipids by phospholipase A2 and phospholipase C activity. Free arachidonic acid can then be converted into the…
