(a) Diffuse large B-cell lymphoma (DLBCL), NOS T-cell/histiocyte rich large B-cell lymphoma (T/HRBCL) EBV + DLBCL of the “elderly” (b) DLBCL with a predominant extranodal location Primary mediastinal (thymic) large B cell…
Adverse event Novel agent Action Dose-reductions Neutropenia Lenalidomide, Bortezomib G-CSF until neutrophil recovery in case of uncomplicated grade 4 or grade 2–3 complicated by fever or infection. 25–50 % drug…
Small lymphocytic lymphoma/ chronic lymphocytic leukemia B-cell prolymphocytic leukemia Splenic marginal zone lymphoma Hairy cell leukemia Splenic B–cell lymphoma/leukemia unclassifiable a Splenic red pulp small B–cell lymphoma a Hairy cell…
Fig. 7.1 Age-distribution among patients with newly diagnosed CLL Biology and Aging The etiology of CLL is unknown and its pathogenesis is not fully understood [2]. The reason why CLL…
Fig. 7.1 Contract-enhanced CT demonstrates vessel erosion in a consolidating infiltrate of the left lung. An apposition thrombus can be depicted in the pulmonary artery of the left lower lobe…
Dosing regimen Duration of infusion (h) MIC (μg/mL) Probability of patients achieving a target T > MIC of 30 % 35 % 40 % 45 % 500 mg every 8…
Fig. 13.1 Algorithm to diagnose and to treat empirically/preemptively CNS infections in hematology patients Lumbar puncture and cerebrospinal fluid (CSF) analysis should follow the algorithm in Fig. 13.1 and are…
Tumor FN-Risk (%) Regimen Breast cancer >20 AC docetaxel, doxorubicin/docetaxel, doxorubicin/paclitaxel, TAC 10–20 AC, EC, docetaxel, FE120C (q4 weeks), CEF <10 CMF Colon cancer 10–20 5-FU/folinic acid FOLFIRI (5-FU/folinic acid/irinotecan)…
Fig. 10.1 Diagnostic procedures and treatment of neutropenic patients with fever and suspected or proven lung infiltrates. CT computed tomography, BAL bronchoalveolar lavage. Dotted lines indicate exceptions from recommended procedure…
Patient-related factors Advanced age (≥65 years) increases risk [26, 28, 108] Performance status ECOG ≥2 increases risk [66, 109] Nutritional status Low serum albumin <35 g/l is associated with increased…
