Oncohema Key

IODOTHYRONINES Part of “CHAPTER 33 – THYROID FUNCTION TESTS“ PROTEIN BOUND CONCENTRATIONS Serum thyroxine (T4) concentration was, for many years, the most useful first-line test of thyroid function. Historically, T4…

THYROID FUNCTION TESTS Robert C. Smallridge The determination of circulating levels of thyroid hormones is essential for an accurate assessment of the functional status of patients. By means of specific…

GENETIC MUTATIONS IN THYROID HORMONE RESISTANCE SYNDROMES Part of “CHAPTER 32 – THYROID HORMONE RESISTANCE SYNDROMES“ Generalized resistance to thyroid hormone is a genetic disease. Most reported cases belong to…

CLINICAL FORMS OF RESISTANCE TO THYROID HORMONE Part of “CHAPTER 32 – THYROID HORMONE RESISTANCE SYNDROMES“ In 1967, a bizarre finding in two young deaf-mute patients was reported by Refetoff…

MODEL OF THYROID-HORMONE RECEPTOR ACTION Part of “CHAPTER 31 – THYROID PHYSIOLOGY: HORMONE ACTION, RECEPTORS, AND POSTRECEPTOR EVENTS“ On the basis of these findings, a model for the mechanism of…

TRANSCRIPTIONAL ACTIVATION BY THYROID HORMONE COACTIVATORS Part of “CHAPTER 31 – THYROID PHYSIOLOGY: HORMONE ACTION, RECEPTORS, AND POSTRECEPTOR EVENTS“ Many factors potentially can modulate TH-mediated transcription. These include variability among…

REPRESSION OF BASAL TRANSCRIPTION/COREPRESSORS Part of “CHAPTER 31 – THYROID PHYSIOLOGY: HORMONE ACTION, RECEPTORS, AND POSTRECEPTOR EVENTS“ Unliganded TRs bind to TREs and can repress transcription of positively regulated target…