Oncohema Key

BIOCHEMISTRY OF BONE Part of “CHAPTER 56 – MARKERS OF BONE METABOLISM“ Bone is composed of ˜70% mineral and 30% organic matter. The mineral, primarily in the form of hydroxyapatite…

MARKERS OF BONE METABOLISM Markus J. Seibel Simon P. Robins John P. Bilezikian Bone is a metabolically active tissue that throughout life undergoes constant remodeling. Skeletal turnover is achieved by…

VARIABLES ROUTINELY MEASURED IN THE ANALYSIS OF THE BIOPSY SPECIMEN Part of “CHAPTER 55 – BONE QUANTIFICATION AND DYNAMICS OF TURNOVER“ An abundance of quantitative information may be obtained from…

TECHNIQUE OF ILIAC CREST BIOPSY Part of “CHAPTER 55 – BONE QUANTIFICATION AND DYNAMICS OF TURNOVER“ PRETREATMENT OF THE PATIENT WITH TETRACYCLINE The information obtainable from an iliac crest biopsy…

ASSESSMENT OF VITAMIN D STATUS Part of “CHAPTER 54 – VITAMIN D“ Because of the wide anatomic distribution of the sites of synthesis, metabolism, and action of vitamin D, clinical…

BIOLOGIC ACTIONS OF VITAMIN D Part of “CHAPTER 54 – VITAMIN D“ INTESTINE CALCIUM TRANSPORT The most important bioeffect of 1,25(OH)2D3 is to increase the intestinal absorption of calcium. Although…

REGULATION OF VITAMIN D METABOLISM Part of “CHAPTER 54 – VITAMIN D“ The metabolic activation of vitamin D is subject to both coarse-and fine-control mechanisms operating at the principal enzymatic…

CHEMISTRY Part of “CHAPTER 54 – VITAMIN D“ Vitamin D and its analogs form a group of fat-soluble secosterols with antirachitic properties.1 The two parent forms of vitamin D are…