GENERAL MECHANISMS OF ACTION

Aug 25, 2016 by in ENDOCRINOLOGY Comments Off on GENERAL MECHANISMS OF ACTION

GENERAL MECHANISMS OF ACTION Part of “CHAPTER 73 – CORTICOSTEROID ACTION“ The steroid hormones, vitamin D, retinoic acid, and the thyroid hormones all share a similar mechanism of action.1,2 These…

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CORTICOSTEROID ACTION

Aug 25, 2016 by in ENDOCRINOLOGY Comments Off on CORTICOSTEROID ACTION

CORTICOSTEROID ACTION Perrin C. White GENERAL MECHANISMS OF ACTION Related posts: REGULATION OF THE GROWTH HORMONE RECEPTOR AND BINDING PROTEIN GONADOTROPE ADENOMAS OF THE PITUITARY PROLACTIN HYPERSECRETION DEFINITIONS THYROID-HORMONE RECEPTOR…

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METABOLISM

Aug 25, 2016 by in ENDOCRINOLOGY Comments Off on METABOLISM

METABOLISM Part of “CHAPTER 72 – SYNTHESIS AND METABOLISM OF CORTICOSTEROIDS“ The liver and the kidney are the principal organs involved in clearing the steroid hormones from the circulation. Although…

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ALTERATIONS IN BINDING PROTEINS

Aug 25, 2016 by in ENDOCRINOLOGY Comments Off on ALTERATIONS IN BINDING PROTEINS

ALTERATIONS IN BINDING PROTEINS Part of “CHAPTER 72 – SYNTHESIS AND METABOLISM OF CORTICOSTEROIDS“ Generally, it is the total level of a hormone that is measured. Many factors can alter…

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DISTRIBUTION IN THE CIRCULATION

Aug 25, 2016 by in ENDOCRINOLOGY Comments Off on DISTRIBUTION IN THE CIRCULATION

DISTRIBUTION IN THE CIRCULATION Part of “CHAPTER 72 – SYNTHESIS AND METABOLISM OF CORTICOSTEROIDS“ Substantial variability exists in the production rate of the various steroids by males and females (see…

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REGULATION OF ADRENAL CORTICOSTEROID PRODUCTION

Aug 25, 2016 by in ENDOCRINOLOGY Comments Off on REGULATION OF ADRENAL CORTICOSTEROID PRODUCTION

REGULATION OF ADRENAL CORTICOSTEROID PRODUCTION Part of “CHAPTER 72 – SYNTHESIS AND METABOLISM OF CORTICOSTEROIDS“ CORTISOL SECRETION ADRENOCORTICOTROPIC HORMONE ACTH is a 39-amino-acid peptide that is produced in the anterior…

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PATHWAYS

Aug 25, 2016 by in ENDOCRINOLOGY Comments Off on PATHWAYS

PATHWAYS Part of “CHAPTER 72 – SYNTHESIS AND METABOLISM OF CORTICOSTEROIDS“ ORIGIN OF CHOLESTEROL Cholesterol, the common precursor of all adrenal steroids, is a 27-carbon compound that originates from three…

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BIOSYNTHESIS

Aug 25, 2016 by in ENDOCRINOLOGY Comments Off on BIOSYNTHESIS

BIOSYNTHESIS Part of “CHAPTER 72 – SYNTHESIS AND METABOLISM OF CORTICOSTEROIDS“ IMPORTATION INTO MITOCHONDRIA The rate-limiting step in steroid biosynthesis is importation of cholesterol from cellular stores to the matrix…

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STRUCTURE AND NOMENCLATURE

Aug 25, 2016 by in ENDOCRINOLOGY Comments Off on STRUCTURE AND NOMENCLATURE

STRUCTURE AND NOMENCLATURE Part of “CHAPTER 72 – SYNTHESIS AND METABOLISM OF CORTICOSTEROIDS“ Steroids have a common structure with 17-carbon atoms arranged in three six-membered rings and a fourth five-membered…

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SYNTHESIS AND METABOLISM OF CORTICOSTEROIDS

Aug 25, 2016 by in ENDOCRINOLOGY Comments Off on SYNTHESIS AND METABOLISM OF CORTICOSTEROIDS

SYNTHESIS AND METABOLISM OF CORTICOSTEROIDS Perrin C. White The adrenal glands are endocrinologically complex organs that are composed of two distinct endocrine tissues derived from different embryologic sources1 (see Chap….

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