“PRIMARY ALDOSTERONISM”
“PRIMARY ALDOSTERONISM” Part of “CHAPTER 80 – HYPERALDOSTERONISM“ Autonomous overproduction of aldosterone occurs in ˜2% of patients with hypertension and was recognized initially as being associated with either a unilateral…
PHYSIOLOGY OF ALDOSTERONE
PHYSIOLOGY OF ALDOSTERONE Part of “CHAPTER 80 – HYPERALDOSTERONISM“ SYNTHESIS The zona glomerulosa cells of the adrenal cortex synthesize aldosterone from corticosterone in a two-step, mixed function oxidation reaction that…
DISORDERS OF MINERALOCORTICOID EXCESS
DISORDERS OF MINERALOCORTICOID EXCESS Part of “CHAPTER 80 – HYPERALDOSTERONISM“ Mineralocorticoid excess, whether primary or secondary, and disorders that mimic it are commonly manifested clinically as hypokalemia, which usually but…
HYPERALDOSTERONISM
HYPERALDOSTERONISM John R. Gill JR. DISORDERS OF MINERALOCORTICOID EXCESS PHYSIOLOGY OF ALDOSTERONE “PRIMARY ALDOSTERONISM” ALDOSTERONE-PRODUCING ADENOMAS Related posts: FUTURE PROSPECTS HEIGHT AND WEIGHT REGULATION OF THE GROWTH HORMONE RECEPTOR AND…
ALDOSTERONE
ALDOSTERONE Part of “CHAPTER 79 – RENIN-ANGIOTENSIN SYSTEM AND ALDOSTERONE“ Aldosterone is the most potent of several mineralocorticoid steroid hormones that act on the epithelium, especially in the kidney, to…
ACTIONS OF ANGIOTENSIN II
ACTIONS OF ANGIOTENSIN II Part of “CHAPTER 79 – RENIN-ANGIOTENSIN SYSTEM AND ALDOSTERONE“ Renal Sodium and Water Retention. The best known function of A-II is to support the circulation under…
ANGIOTENSIN RECEPTORS
ANGIOTENSIN RECEPTORS Part of “CHAPTER 79 – RENIN-ANGIOTENSIN SYSTEM AND ALDOSTERONE“ A-II binds and acts on its receptors at the cell surface. Several receptor subtypes have been found, including the…
TISSUE RENIN-ANGIOTENSIN SYSTEM
TISSUE RENIN-ANGIOTENSIN SYSTEM Part of “CHAPTER 79 – RENIN-ANGIOTENSIN SYSTEM AND ALDOSTERONE“ Local renin-angiotensin systems in multiple tissues can produce A-II independently of the circulating renin-angiotensin system (Table 79-1). Their…
ANGIOTENSIN METABOLISM
ANGIOTENSIN METABOLISM Part of “CHAPTER 79 – RENIN-ANGIOTENSIN SYSTEM AND ALDOSTERONE“ Of the several active angiotensins, A-II is the most important. The enzymes that are most active in degrading angiotensin…
ANGIOTENSIN I-CONVERTING ENZYME
ANGIOTENSIN I-CONVERTING ENZYME Part of “CHAPTER 79 – RENIN-ANGIOTENSIN SYSTEM AND ALDOSTERONE“ Angiotensin I-converting enzyme (ACE) converts the inactive decapeptide angiotensin I to the active octapeptide angiotensin II (Fig. 79-4)….
