MINERALOCORTICOID RESISTANCE Part of “CHAPTER 81 – HYPOALDOSTERONISM“ Mineralocorticoid resistance implies a lack of response to aldosterone despite its presence. Aldosterone binds to intracellular mineralocorticoid receptors, which interact with DNA….
ISOLATED HYPOALDOSTERONISM Part of “CHAPTER 81 – HYPOALDOSTERONISM“ Isolated hypoaldosteronism, a selective deficiency of aldosterone secretion without alteration in cortisol production, results in a persistent hyperkalemia, which may be associated…
HYPOALDOSTERONISM James C. Melby ISOLATED HYPOALDOSTERONISM Related posts: REGULATION OF THE GROWTH HORMONE RECEPTOR AND BINDING PROTEIN GONADOTROPE ADENOMAS OF THE PITUITARY PROLACTIN HYPERSECRETION DEFINITIONS THYROID-HORMONE RECEPTOR BINDING TO THYROID…
BARTTER SYNDROME Part of “CHAPTER 80 – HYPERALDOSTERONISM“ CLINICAL FEATURES AND PATHOPHYSIOLOGY Bartter syndrome includes a number of disorders of tubular transport that may be familial or acquired as a…
SECONDARY HYPERALDOSTERONISM Part of “CHAPTER 80 – HYPERALDOSTERONISM“ A variety of disorders of the kidney, heart, liver, and gastrointestinal tract may lead to hyperreninemia and, in turn, to hyperaldosteronism and…
SYNDROMES OF REAL OR APPARENT MINERALOCORTICOID EXCESS NOT CAUSED BY ALDOSTERONE Part of “CHAPTER 80 – HYPERALDOSTERONISM“ CLINICAL FEATURES AND PATHOPHYSIOLOGY Occasionally, patients may have features of mineralocorticoid excess (hypokalemic…
ADRENOCORTICAL CARCINOMA Part of “CHAPTER 80 – HYPERALDOSTERONISM“ CLINICAL FEATURES AND PATHOPHYSIOLOGY Adrenocortical carcinoma is an extremely rare cause of hyperal-dosteronism and accounts for fewer than 2% of aldosterone-producing tumors.52,52a…
DEXAMETHASONE-SUPPRESSIBLE HYPERALDOSTERONISM Part of “CHAPTER 80 – HYPERALDOSTERONISM“ CLINICAL FEATURES AND PATHOPHYSIOLOGY Dexamethasone-suppressible hyperaldosteronism (glucocorticoid-remediable aldosteronism) is a rare familial disorder inherited as an autosomal-dominant trait that exhibits the clinical…
IDIOPATHIC HYPERALDOSTERONISM Part of “CHAPTER 80 – HYPERALDOSTERONISM“ CLINICAL FEATURES AND PATHOPHYSIOLOGY Idiopathic bilateral adrenocortical hyperplasia of the zona glomerulosa (idiopathic hyperaldosteronism) is characterized by features similar to those associated…
ALDOSTERONE-PRODUCING ADENOMAS Part of “CHAPTER 80 – HYPERALDOSTERONISM“ CLINICAL FEATURES AND PATHOPHYSIOLOGY Aldosterone-producing adrenocortical adenomas usually are small (0.5–2.5 cm), unilateral, solitary, and associated with hypoplastic zona glomerulosa. Occasionally, however,…
