GROWTH HORMONE–BINDING PROTEIN
GROWTH HORMONE–BINDING PROTEIN Part of “CHAPTER 12 – GROWTH HORMONE AND ITS DISORDERS“ The GHBP is the soluble, extracellular domain of the GHR. In humans and many other species, the…
GROWTH HORMONE RECEPTOR
GROWTH HORMONE RECEPTOR Part of “CHAPTER 12 – GROWTH HORMONE AND ITS DISORDERS“ The GH receptor (GHR) is a 620-amino-acid, ˜130 kDa, single-chain glycoprotein with a single transmembrane domain, a…
GROWTH HORMONE STRUCTURE
GROWTH HORMONE STRUCTURE Part of “CHAPTER 12 – GROWTH HORMONE AND ITS DISORDERS“ Human GH is heterogeneous and consists of several molecular variants (Fig. 12-2).2 The principal form is a…
GROWTH HORMONE GENES
GROWTH HORMONE GENES Part of “CHAPTER 12 – GROWTH HORMONE AND ITS DISORDERS“ In humans, GH is encoded by two genes on the long arm of chromosome 17.1 They are…
GROWTH HORMONE AND ITS DISORDERS
GROWTH HORMONE AND ITS DISORDERS Gerhard Baumann Growth hormone (GH) is a polypeptide hormone produced by the somatotrope cells in the pituitary gland. It is the master anabolic hormone and…
PITUITARY NEOPLASMS
PITUITARY NEOPLASMS Part of “CHAPTER 11 – MORPHOLOGY OF THE PITUITARY IN HEALTH AND DISEASE“ Numerous tumor types occur in the sellar region; they can be epithelial or mesenchymal and…
PATHOLOGY OF THE NEUROHYPOPHYSIS AND HYPOTHALAMUS2,4,10,19
PATHOLOGY OF THE NEUROHYPOPHYSIS AND HYPOTHALAMUS2,4,10,19 Part of “CHAPTER 11 – MORPHOLOGY OF THE PITUITARY IN HEALTH AND DISEASE“ Clinically significant diseases of the posterior lobe are rare. Endocrinologically, they…
THE ABNORMAL ADENOHYPOPHYSIS1a,2
THE ABNORMAL ADENOHYPOPHYSIS1a,2 Part of “CHAPTER 11 – MORPHOLOGY OF THE PITUITARY IN HEALTH AND DISEASE“ Diseases of the adenohypophysis can be broadly divided into (a) developmental abnormalities; (b) vascular…
THE NORMAL PITUITARY1,2
THE NORMAL PITUITARY1,2 Part of “CHAPTER 11 – MORPHOLOGY OF THE PITUITARY IN HEALTH AND DISEASE“ EMBRYOLOGY The pituitary gland is derived from two sources. The epithelial part, which includes…
MORPHOLOGY OF THE PITUITARY IN HEALTH AND DISEASE
MORPHOLOGY OF THE PITUITARY IN HEALTH AND DISEASE Kamal Thapar Kalman Kovacs Eva Horvath In 1886, the French neurologist Pierre Marie proposed that the pituitary gland plays a fundamental role…
