♦Chlorambucil
♦Chlorambucil (klor-am’-byoo-sil) Leukeran Pregnancy Category D Mechanism of Action Chlorambucil is a nitrogen mustard derivative that works as an alkylating agent by interfering with DNA replication and the transcription of…
♦Carmustine
♦Carmustine (car-mus’-teen) BCNU, BICNU Pregnancy Category D Mechanism of Action A cell cycle-nonspecific alkylating agent, carmustine is a ni-trosourea derivative that alkylates DNA by causing cross-links and strand breaks. Indications…
♦Carboplatin
♦Carboplatin (kar’-bo-pla-tin) Paraplatin, CBDCA Pregnancy Category D Mechanism of Action Carboplatin is a cell cycle-nonspecific alkylating agent that prevents cell replication by producing intra- and inter-DNA cross-links. Indications Ovarian cancer…
♦Capecitabine
♦Capecitabine (kap-ah-ceet’-a-bean) Xeloda Pregnancy Category D Mechanism of Action Capecitabine is a prodrug to be activated preferentially at tumor sites, thus improving the therapeutic efficacy of 5-fluorouracil (5-FU). This drug…
♦Bleomycin
♦Bleomycin (blee-oh-mye’-sin) Blenoxane Pregnancy Category D Mechanism of Action A cell cycle-specific antitumor antibiotic that inhibits DNA, RNA, and protein synthesis. Indications Palliative treatment of lymphomas; squamous cell carcinoma of…
♦Bicalutamide
♦Bicalutamide (bye-ka-loo’-ta-myde) Casodex Pregnancy Category X Mechanism of Action Bicalutamide is a nonsteroidal antiandrogen that inhibits the uptake and binding of androgens to the androgen receptors in the prostate gland…
♦Anastrozole
♦Anastrozole (an-as’-troo-zol) Arimidex Pregnancy Category C Mechanism of Action Anastrozole is a selective nonsteroidal aromatase inhibitor. Many breast cancers have estrogen receptors; the growth of these tumors is stimulated by…
♦Aminoglutethimide
♦Aminoglutethimide (a-meen-oh-glow-teth’-i-mide) Cytadren Pregnancy Category D Mechanism of Action Inhibits adrenocortical steroid synthesis by blocking the production of adrenal glucocorticoids, mineralocorticoids, estrogens, and androgens. Indications Suppression of adrenal function in…
♦Amifostine
♦Amifostine (a-mee-phos’-tin) Ethyol Pregnancy Category C Mechanism of Action Amifostine is dephosphorylated at the tissue site by alkaline phosphatase to form free thiol. Once inside the cell, the free thiol…
