♦Docetaxel
♦Docetaxel (doh-see-tax’-el) Taxotere Pregnancy Category D Mechanism of Action Docetaxel belongs to the taxoid family and acts by disrupting the microtubular network in the cells, which is essential for their…
♦Diethylstilbestrol Diphosphate
♦Diethylstilbestrol Diphosphate (diey-e-thil-stil-bes’-trol) Stilphostrol Pregnancy Category D Mechanism of Action Unknown. Diethylstilbestrol is an estrogen that affects the hormonal milieu of the body. Indications ♦ Inoperable prostate cancer ♦ Postmenopausal…
♦Dexrazoxane
♦Dexrazoxane (dex-ra’-zoo-zayne) Zinecard Pregnancy Category C Mechanism of Action Dexrazoxane is a chelating agent that interferes with iron-mediated radicals thought to be responsible for anthracycline-induced cardiotoxicity. Indications Reduction of the…
♦Daunorubicin Hydrochloride
♦Daunorubicin Hydrochloride (daw-no-roo’ bi-sin) Cerubidine, Rubidomycin Hydrochloride Pregnancy Category C Mechanism of Action Daunorubicin is a cytotoxic, anthracycline antibiotic that inhibits the synthesis of DNA. It has antimitotic and immunosuppressive…
♦Dactinomycin
♦Dactinomycin (dak-tee-no-my’-seen) Actinomycin, Cosmegen Pregnancy Category C Mechanism of Action Dactinomycin is a cell cycle-nonspecific, antitumor antibiotic that interferes with RNA synthesis. Indications ♦ Wilms’ tumor ♦ Rhabdomyosarcoma ♦ Ewing’s…
♦Dacarbazine
♦Dacarbazine (de-kar’-ba-zeen) DTIC-Dome Pregnancy Category C Mechanism of Action The activity may be the result of three mechanisms: alkylation, antimetabolite activity as a purine precursor, and interaction with sulfhydryl groups…
♦Cytarabine
♦Cytarabine (cye-tar’-a-been) ARA-C, cytosine arabinoside, Cytosar-UR Pregnancy Category D Mechanism of Action Cytarabine is a cell cycle-specific (S phase) antimetabolite that inhibits cell development from the G1 to the S…
♦Cyclophosphamide
♦Cyclophosphamide (cy-klo-foss’-fa-mide) Cytoxan, Neosar Pregnancy Category D Mechanism of Action Cyclophosphamide is a cell cycle-nonspecific nitrogen mustard derivative that acts as an alkylating agent by interfering with DNA replication and…
♦Cladribine
♦Cladribine (kla’-drih-been) Leustatin Pregnancy Category D Mechanism of Action Unclear. A high intracellular concentration of cladribine is believed to inhibit ribonucleotide reductase, causing subsequent DNA strand breaks and inhibition of…
♦Cisplatin
♦Cisplatin (sis’-pla-teen) CDDP, Platinol Pregnancy Category D Mechanism of Action Cisplatin is a widely used heavy metal, cell cycle-nonspecific agent that interferes with cell division by binding to DNA and…
