♦Interferon-alfa-2b (in-ter-feer’-on) Intron-A, IFN-alpha 2 Pregnancy Category C Mechanism of Action Interferon exerts antitumor activities through antiviral replication, immunomodulatory, and antiproliferative biologic effects. Its direct antiproliferative properties may explain its…
♦Interferon-alfa-2a (in-ter-feer’-on) Roferon-A, rIFN-A Pregnancy Category C Mechanism of Action Not clearly understood; exerts antitumor activity through an-tiviral, antiproliferative, and immunomodulatory biologic effects. Indications ♦ Hairy cell leukemia and AIDS-related…
♦Ifosfamide (eye-fos’-fa-myde) Ifex Pregnancy Category D Mechanism of Action Ifosfamide is an alkylating agent that is cell cycle-nonspecific. It is an analogue of cyclophosphamide that acts by alkylating DNA and…
♦Idarubicin Hydrochloride (eye-da-roo’-bee-sin) Idamycin Pregnancy Category D Mechanism of Action Idarubicin is an intercalating analogue of daunorubicin, which inhibits nucleic acid synthesis and interacts with the enzyme topoisomerase. Indications Acute…
♦Hydroxyurea (hye-drox-ee-yoor-ee’-ya) Hydrea Pregnancy Category D Mechanism of Action Unknown. It is thought to cause an immediate inhibition of DNA synthesis without interfering with the synthesis of RNA or protein….
♦Goserelin Acetate (goe’-se-rel-in) Zoladex Pregnancy Category X Mechanism of Action This drug is an analogue for luteinizing hormone-releasing hormone and acts on the pituitary hormone to inhibit the secretion of…
♦Gemcitabine (gem-see’-ta-bean) Gemzar Pregnancy Category D Mechanism of Action Gemcitabine is a cell cycle-specific (S phase) cytotoxic agent that kills cells in the S phase undergoing DNA synthesis. It also…
♦Flutamide (floo’-ta-mide) Eulexin Pregnancy Category D Mechanism of Action This drug is a potent nonsteroidal agent that acts by inhibiting the uptake of androgen or the nuclear binding of androgen…
♦Fluorouracil (flure-oh-yoor’-a-seel) 5-FU, Adrucil Pregnancy Category D Mechanism of Action Interferes with DNA synthesis and formation of RNA, which are essential for cell division and growth. Causes a thymine deficiency,…
♦Fludarabine Phosphate (floo-dar’-a-been) Fludara Pregnancy Category D Mechanism of Action Fludarabine is an antimetabolite that inhibits DNA synthesis by inhibiting ribonucleic reductase, DNA polymerase, and DNA primase. Indications Used in…
