♦Streptozocin (strep-toe-zoe’-sin) Zanosar Pregnancy Category C Mechanism of Action A nitrosourea alkylating agent that causes cell lysis by impairing DNA synthesis through intrastrand cross-linking of DNA. Indications Pancreatic carcinoma, colon…
♦Satumomab Pendetide (sah-too’-moe-mab) OncoScint, CR/OV Pregnancy Category C Mechanism of Action A conjugate from a murine monoclonal antibody that localizes or binds to a tumor-associated antigen (TAG-72). Indications To determine…
♦Sargramostim (sar-gram’-oh-stim) Leukine Pregnancy Category C Mechanism of Action Activates mature granulocytes and macrophages; promotes the proliferation and differentiation of hematopoietic progenitor cells. Indications ♦ To accelerate neutrophil recovery and…
♦Procarbazine (pro-kar’-ba-zeen) Matulane Pregnancy Category D Mechanism of Action Unclear; possible inhibition of DNA, RNA and protein synthesis, and alkylation of DNA. Cell cycle-specific with greatest activity during S phase….
♦Porfimer Sodium (poor’-fa-mer) Photofrin Pregnancy Category C Mechanism of Action Acts as a photosensitizer in tissue exposed to light wave lengths >600 nm delivered by a laser to destroy tumor…
♦Plicamycin (plye-kay-mye’-sin) Mithramycin, Mithracin Pregnancy Category X Mechanism of Action An antitumor antibiotic that binds to DNA and inhibits DNA-directed RNA synthesis. Acts on osteoclasts and blocks the action of…
♦Pipobroman (pip-o-bro’-man) Vercyte Pregnancy Category: Not Available Mechanism of Action Unknown; pipobroman is a polyfunctional cytotoxic alkylating agent that is cell cycle-nonspecific. Indications Polycythemia vera, chronic granulocytic leukemia. Metabolism/Excretion Related…
♦Pentostatin (pen’-toe-stah-tin) Nipent Pregnancy Category D Mechanism of Action An antitumor antibiotic that inhibits the ADA enzyme and causes cell lysis. Indications Alpha-interferon-refractory hairy cell leukemia in adults. Metabolism/Excretion Metabolized…
♦Pegasparagase (peg-ass-par’-a-gase) Oncaspar Pregnancy Category C Mechanism of Action A derivative of the L-asparaginase enzyme, which destroys the amino acid asparagine needed for cancer cell proliferation. Inhibits malignant cell production….
♦Pamidronate Disodium (pam-ee’-dro-nayt) Aredia Pregnancy Category C Mechanism of Action Believed to inhibit bone resorption by blocking the dissolution of calcium phosphate crystals in the bone. Indications Osteolytic bone metastases…
