Oncohema Key

♦Vinblastine (vin-blas’-teen) Velban, VLB Pregnancy Category D Mechanism of Action A cell cycle-specific vinca alkaloid that inhibits mitotic spindle formation by binding to tubulin. Most specific for the M phase….

♦Uracil Mustard (yoor’-a-sill) Pregnancy Category X Mechanism of Action An alkylating agent that binds to DNA, inhibits DNA synthesis, and leads to cell death. Indications Chronic lymphoblastic leukemia, chronic myelogenous…

♦Tretinoin (tret’-i-noyn) Retinoic acid, Vesanoid Pregnancy Category D Mechanism of Action Not understood. This natural retinoid may play a role in hematopoiesis and immune function. Inhibits the proliferation of acute…

♦Topotecan Hydrochloride (toe-poe’-tee-kan) Hycamtin Pregnancy Category D Mechanism of Action A semisynthetic derivative of camptothecin, topotecan inhibits the activity of topoisomerase I, an enzyme necessary for DNA replication. Indications Metastatic…

♦Thiotepa (thy-oh-tep’-ah) Triethylene, Thio-Tepa, TESPA, TSPA Pregnancy Category D Mechanism of Action An alkylating agent that alters DNA replication, RNA transcription, and nucleic acid formation, resulting in cell death. Indications…

♦Thioguanine (thye-oh-gwah’-neen) TG, 6-thioguanine, Tabloid Pregnancy Category D Mechanism of Action An antimetabolite that inhibits purine synthesis by substituting for the nucleotide guanine. S phase-specific. Indications Acute lymphocyte leukemia, acute…

♦Testolactone (tess-toe-lak’-tone) Teslac Pregnancy Category X Mechanism of Action An androgen estrogen antagonist that impairs tumor growth by suppressing pituitary function. Indications Advanced breast carcinoma, refractory anemia. Metabolism/Excretion Metabolized in…

♦Teniposide (teh-nip’-oh-side) VM-26, Vumon Pregnancy Category D Mechanism of Action A phase-specific drug that causes DNA strand breakage and the inhibition of type II topoisomerase, which leads to cell death….

♦Temozolomide (teh-moo-zoh’-loh-mide) Temodar Pregnancy Category D Mechanism of Action Not directly active, but undergoes rapid nonenzymatic conversion to the reactive compound 5-(3-methyltriazen-1-y) im-idazole-4-carboxamide (MTIC). The cytotoxic action of MTIC is…

♦Tamoxifen (ta-mox’-i-fen) Nolvadex Pregnancy Category D Mechanism of Action An antiestrogen that competes for estrogen binding sites in breast tissue. Indications Axillary node-negative breast cancer in women after total or…