Kinase Inhibitors as Anticancer Drugs Charles L. Sawyers INTRODUCTION In 2001, the first tyrosine-kinase inhibitor imatinib was approved for clinical use in chronic myeloid leukemia. The spectacular success of this…
Antimicrotubule Agents Christopher J. Hoimes Lyndsay N. Harris MICROTUBULES Microtubules are vital and dynamic cytoskeletal polymers that play a critical role in cell division, signaling, vesicle transport, shape, and polarity,…
Antimetabolites M. Wasif Saif Edward Chu ANTIFOLATES Reduced folates play a key role in one-carbon metabolism, and they are essential for the biosynthesis of purines, thymidylate, and protein biosynthesis. Aminopterin…
Platinum Analogs Peter J. O’Dwyer A. Hilary Calvert INTRODUCTION The platinum drugs represent a unique and important class of antitumor compounds. Alone or in combination with other chemotherapeutic agents, cis-diamminedichloroplatinum…
Pharmacogenomics Christine M. Walko Howard L. McLeod INTRODUCTION The evolution of understanding cancer biology has yielded many advances that have been translated into cancer treatment. Application of this knowledge has…
Pharmacokinetics and Pharmacodynamics of Anticancer Drugs Alex Sparreboom Sharyn D. Baker INTRODUCTION Drug selection and therapy considerations in oncology were originally solely based on observations of the effects produced.1 To…
Cancer Immunotherapy Steven A. Rosenberg Paul F. Robbins Giao Q. Phan Steven A. Feldman James N. Kochenderfer INTRODUCTION Progress in understanding basic aspects of cellular immunology and tumor-host immune interactions…
Essentials of Radiation Therapy Meredith A. Morgan Randall K. Ten Haken Theodore S. Lawrence INTRODUCTION The beneficial use of radiation was launched by the experiments of Wilhelm Roentgen, who, in…
Trends in United States Cancer Mortality Tim E. Byers INTRODUCTION Cancer incidence registries now cover nearly all of the US population. State-based vital records systems and aggregate national systems regularly…
Epidemiologic Methods Xiaomei Ma Herbert Yu INTRODUCTION Epidemiology is the study of the distribution and determinants of health-related states or events in specified populations and the application of this study…
