Megakaryocyte Structure and Platelet Biogenesis Joseph E. Italiano Jr. John H. Hartwig INTRODUCTION The process of making platelets is both amazing and bewildering. In the humans, 108 megakaryocytes are born…
Platelet Production: Cellular and Molecular Regulation Elisabeth Cramer BordÉ William Vainchenker Platelets are derived from the fragmentation of the cytoplasm of giant bone marrow cells, the megakaryocytes (MKs). MKs are…
Overview of Megakaryocyte and Platelet Biology Joel S. Bennett Platelets are circulating anucleate fragments of bone marrow megakaryocytes that provide primary hemostasis by forming hemostatic plugs at sites of vascular…
Inhibitors of Fibrinolysis BjÖRn Wiman Anna ÅGren The fibrinolytic system has many different functions in vivo. Within the blood vessels, its main function is to remove fibrin deposits and keep…
Plasminogen Activation and Regulation of Fibrinolysis Nicola J. Mutch Nuala A. Booth Hemostasis requires mechanisms both to stop bleeding by formation of a hemostatic plug and to dissolve this plug…
Protein C, Protein S, Thrombomodulin, and the Endothelial Protein C Receptor Pathways Laurent O. Mosnier John H. Griffin THE PROTEIN C PATHWAYS—OVERVIEW Control of coagulation reactions is essential for normal…
Antithrombin and the Serpin Family Susan C. Bock ANTITHROMBIN III Overview Antithrombin III (ATIII) is a plasma proteinase inhibitor that inactivates thrombin and the enzymes responsible for the generation of…
Factor XIII CéDric Duval Helen Phiuppou Robert A.S. AriëNs Factor XIII (FXIII) is an unusual blood coagulation factor, circulating as a heterotetramer composed of two catalytic A-subunits and two noncatalytic…
Fibrinogen Structure and Function John W. Weisel Carl-Erik H. Dempfle Fibrinogen, originally factor I (FI) in the clotting cascade, is a fibrous adhesive glycoprotein, present in the plasma at a…
The Factor XII-Driven Plasma Contact System Thomas RennÉ SUMMARY The contact system is a protease cascade that is initiated by coagulation factor XII activation and operates on cardiovascular cells. The…
