Platelet Signal Transduction
Platelet Signal Transduction Charles S. Abrams Lawrence F. Brass Platelets become activated when agonists such as collagen or thrombin bind to receptors on the platelet surface, initiating intracellular signaling events…
Molecular Basis for Platelet Secretion
Molecular Basis for Platelet Secretion Shaojing Ye Sidney W. Whiteheart INTRODUCTION Platelets are small, anucleate, discoid cell fragments produced by bone marrow megakaryocytes. Structurally, platelets are simple, containing plasma membrane…
Integrín αIIbβ3 and Platelet Aggregation
Integrín αIIbβ3 and Platelet Aggregation Ana Kasirer-Friede Kamila Bledzka Jun Qin Edward F. Plow Sanford J. Shattil PERSPECTIVE In 1977, Phillips and Agin1 provided important insight into the hemostatic function…
Platelet Collagen Receptors
Platelet Collagen Receptors Stephen P. Watson Richard W. Farndale Masaaki Moroi Stephanie M. Jung Platelets, small anucleate circulating blood cells, are known to be activated by several physiologic substances, including…
Shear Effects on Platelets and the Vessel Wall in the Pathogenesis of Atherothrombosis
Shear Effects on Platelets and the Vessel Wall in the Pathogenesis of Atherothrombosis David L. Bark Jr. Warwick S. Nesbitt Angus K.T. Wong Shaun P. Jackson The hemodynamic effects of…
The Basis for Platelet Adhesion
The Basis for Platelet Adhesion Brian Savage Zaverio M. Ruggeri PERSPECTIVE Mammalian platelets are circulating fragments of bone marrow megakaryocytes1,2 that function primarily to maintain the integrity of the vasculature…
Platelet Glycoprotein Polymorphisms and Relationship to Function and Immunogenicity
Platelet Glycoprotein Polymorphisms and Relationship to Function and Immunogenicity Thomas J. Kunicki Diane J. Nugent In order to place the effect of glycoprotein gene polymorphisms on platelet function and immunogenicity…
Major Platelet Glycoproteins: Integrin αIIbβ3 (GPIIb-IIIa)
Major Platelet Glycoproteins: Integrin αIIbβ3 (GPIIb-IIIa) Feng Ye Mark H. Ginsberg The first insight into the involvement of the integrin αIIbβ3 in hemostasis came from the observation that two major…
Major Platelet Glycoproteins: Platelet Glycoprotein Ib-IX-V
Major Platelet Glycoproteins: Platelet Glycoprotein Ib-IX-V Michael C. Berndt Robert K. Andrews In the past 5 years, understanding of the structure and function of the platelet glycoprotein (GP) Ib-IX-V complex1,2…
Thrombopoietin
Thrombopoietin Kenneth Kaushansky Ian Hitchcock HISTORY The term erythropoietin (EPO) was coined at the turn of the last century to describe the humoral substance responsible for red cell production. At…
