Inherited Thrombocytopenias
Inherited Thrombocytopenias Paquita Nurden Alan T. Nurden Bleeding syndromes arising from an inherited defect of platelet production are an important group of rare diseases with a variety of causes.1,2,3,4 Some,…
Drug-Induced Thrombocytopenia
Drug-Induced Thrombocytopenia Richard H. Aster James N. George BACKGROUND Drugs induce thrombocytopenia through various mechanisms. The inhibition of platelet production is an expected result of the dose-dependent toxicity of chemotherapeutic…
Immune Thrombocytopenia and Posttransfusion Purpura
Immune Thrombocytopenia and Posttransfusion Purpura Howard A. Liebman Douglas B. Cines James B. Bussel IMMUNE THROMBOCYTOPENIA Immune thrombocytopenia (ITP) is a heterogeneous autoimmune disorder characterized by thrombocytopenia with or without…
Differential Diagnosis of Thrombocytopenia
Differential Diagnosis of Thrombocytopenia Joel S. Bennett Charles S. Abrams Thrombocytopenia is encountered frequently in clinical practice, engendering substantial and appropriate concern about its etiology and the consequent risk and…
Overview of Acquired and Inherited Clinical Platelet Disorders
Overview of Acquired and Inherited Clinical Platelet Disorders Joel S. Bennett An insufficient number of platelets (thrombocytopenia) or impaired platelet function (thrombocytopathia) can produce bleeding. Both situations are encountered frequently…
Laboratory Markers of Activated Coagulation and Its Regulation
Laboratory Markers of Activated Coagulation and Its Regulation Kenneth A. Bauer Helen A. Ireland The development of blood tests to predict thrombotic events, or to confirm or exclude the presence…
Acquired Disorders of Coagulation: The Immune Coagulopathies
Acquired Disorders of Coagulation: The Immune Coagulopathies Charles R.M. Hay The formation of a blood clot is the final result of a cascade of interactions among multiple plasma proteins that…
Clinical Disorders of Fibrinolysis
Clinical Disorders of Fibrinolysis Daphne B. Stewart Charles W. Francis Victor J. Marder Excessive promotion or inhibition of fibrinolysis interferes with the hemostatic balance and can lead to clinical bleeding…
Familial Multiple Coagulation Factor Deficiencies
Familial Multiple Coagulation Factor Deficiencies Bin Zhang David Ginsburg The familial multiple coagulation factor deficiencies (FMFDs) are a group of rare inherited disorders characterized by a simultaneous decrease in the…
Afibrinogenemias and Dysfibrinogenemias
Afibrinogenemias and Dysfibrinogenemias Dennis K. Galanakis Congenital fibrinogen disorders have provided novel insights into structure/function relationships and into the central role of fibrinogen in hemostasis. They are generally classified as…
