Clinical Manifestations and Diagnosis of Venous Thromboembolism Henri Bounameaux Arnaud Perrier Pulmonary embolism (PE), the source of which is predominantly located in a thrombosis of the deep veins of the…
Epidemiology and Risk Factors for Venous Thromboembolism John A. Heit Thrombosis can affect virtually any venous circulation. This chapter focuses on the epidemiology of common deep vein thrombosis (DVT) of…
Thrombophilia Genetics Joseph Emmerich Martine Aiach Pierre-Emmanuel Morange Each year, approximately 1 in 1,000 individuals in industrialized countries develops deep-vein thrombosis (DVT) of the lower extremities.1,2 Between 1% and 2%…
Overview of Venous Thromboembolism Sam Schulman Victor J. Marder Gilbert C. White II HISTORICAL BACKGROUND Thrombosis as a clinical condition was probably described almost 5,000 years ago, when the Chinese…
New Approaches for the Therapy of Bleeding Disorders, Including Gene Therapy Gilbert C. White II Harold R. Roberts Better understanding of the molecular mechanisms of blood coagulation and the structure…
Platelets, Plasma, and Specialized Coagulation Concentrate Therapies Thomas S. Kickler The biggest driving force in improving the safety of transfusion therapy in bleeding disorders has been the concern by patients…
Therapy with Antifibrinolytic Agents Daphne B. Stewart Victor J. Marder After hemostasis is established in an injured vessel, a highly orchestrated process follows to heal the vessel and to reestablish…
Management of Acute Hemorrhage Micah J. Mooberry Rommel P. Lu Nigel S. Key Evaluation and management of the acutely bleeding patient is a common encounter for the hematologist and is…
Overview of Therapy of Bleeding Disorders Gilbert C. White II Sam Schulman Victor J. Marder Historically, once it was recognized that blood clotting factors were components of plasma, the notion…
Retinopathy Jing Chen Andreas Stahl Lois E. H. Smith The eye is one of the most important sensory organs that enables us to perceive the environment to ensure species survival….
