Increased understanding of the molecular genetics of acute myeloid leukemia (AML) has uncovered several mutations in genes with a role in the epigenetic regulation of gene transcription, including mutations in…
Martin S. Tallman, MD, Guest Editor The acute leukemias represent a heterogeneous group of malignant hematopoietic stem cell disorders with myeloid characteristics. Remarkable insights have occurred in our understanding of…
Radiation plays an integral role in the management of gynecologic cancers. The specific regimen must be carefully coordinated based on the details of a patient’s personal history and pathologic findings….
Regardless of cancer origin or age of onset, the disease and its treatment can produce short- and long-term sequelae (ie, sexual dysfunction, infertility, or lymphedema) that adversely affect quality of…
Improved understanding of the molecular basis of gynecologic cancers in addition to the availability of faster and less expensive technologies for genetic analysis of cancers has led to the exciting…
Gestational trophoblastic neoplasms are malignant lesions that arise from placental villous and extravillous trophoblast. Four clinicopathologic conditions make up this entity: invasive mole (IM), choriocarcinoma (CCA), placental-site trophoblastic tumor (PSTT),…
Surgical management of ovarian cancer requires excellent judgment and mastery of a wide array of procedures. Involvement of a gynecologic oncologist improves outcomes. Staging of apparent stage I disease is important….
Vulvar cancer is surgically staged and is categorized by the pathologic evaluation of the vulvar tumor and the inguinofemoral lymph nodes. All tumors more invasive than 1 mm and larger…
The incidence and mortality of cervical cancer have decreased dramatically over the past 70 years in well-developed countries through successful screening programs using cytologic examination, followed by evaluation and treatment…
Hereditary cancer syndromes are responsible for 5% of endometrial cancers and 10% of ovarian cancers. Hereditary breast and ovarian cancer syndrome and Lynch syndrome account for most of these inherited…
