Oncohema Key

ADRENOCORTICAL INSUFFICIENCY D. Lynn Loriaux SYNDROMES OF ADRENAL INSUFFICIENCY PRIMARY ADRENAL INSUFFICIENCY

TREATMENT OF CUSHING DISEASE Part of “CHAPTER 75 – CUSHING SYNDROME“ Optimal treatment of Cushing disease depends on an accurate diagnosis of the underlying pathology. Four approaches are used in…

DIFFERENTIAL DIAGNOSIS OF CUSHING-TYPE HYPERCORTISOLISM AND PSEUDO–CUSHING SYNDROME Part of “CHAPTER 75 – CUSHING SYNDROME“ The biochemical and phenotypic presentation of patients with mild hypercortisolism in Cushing syndrome is often…

PSEUDO–CUSHING SYNDROME Part of “CHAPTER 75 – CUSHING SYNDROME“ Hypercortisolism may exist in patients who do not have true Cushing syndrome. These patients experience obesity, depression, alcoholism, anorexia nervosa, bulimia,…

ANATOMIC LOCALIZATION Part of “CHAPTER 75 – CUSHING SYNDROME“ DETECTION OF PITUITARY LESIONS After the diagnosis of Cushing disease has been established on clinical and biochemical grounds, the presence of…

DIAGNOSIS Part of “CHAPTER 75 – CUSHING SYNDROME“ STANDARD DIAGNOSTIC EVALUATION A biochemical evaluation of Cushing syndrome is necessary for confirming the clinical diagnosis and for determining the presence of…

CLINICAL PRESENTATIONS Part of “CHAPTER 75 – CUSHING SYNDROME“ The clinical manifestations of Cushing syndrome are determined by the increased abnormal secretion of cortisol, ACTH, and other adrenocortical steroids under…

CORTICOTROPIN-INDEPENDENT CUSHING SYNDROME Part of “CHAPTER 75 – CUSHING SYNDROME“ Primary nodular hyperplasia, adrenocortical adenomas, and carcinomas as well as rare cases of ectopic cortisol production by tumor are found…

CORTICOTROPIN-DEPENDENT CUSHING SYNDROME Part of “CHAPTER 75 – CUSHING SYNDROME“ PITUITARY CORTICOTROPIN-DEPENDENT CUSHING SYNDROME Approximately 85% of patients with pituitary ACTH-dependent Cushing syndrome, also called Cushing disease, have pituitary microadenomas….

PATHOPHYSIOLOGY Part of “CHAPTER 75 – CUSHING SYNDROME“ Cushing syndrome can be exogenous, resulting from the administration of glucocorticoids or ACTH, or endogenous, resulting from a primary increased secretion of…