Because hemangiomas may involute spontaneously, waiting for spontaneous regression remains a viable therapeutic option. But the “wait-and-see” principle is always wrong (Table 10.2). If it means that treatment arrives too late, then “see and wait” as a control is correct, because at the first sign of progression of complication an action can be taken. Therefore, in case of small, uncomplicated infantile hemangiomas in non-problematic areas (extremities, body) without any tendency to proliferate, especially in cutaneous hemangiomas, one can “see and wait.” If delayed growth cannot be excluded, frequent controls are required. Clinical checkups alone may not be sufficient, as subcutaneous infantile hemangiomas may remain unnoticed as they grow deeply and are then only recognized after complications result. This is why a periodic duplex scan control is mandatory. For hemangiomas in the quiescent or regression phase, a “see-and-wait” attitude should normally be recommended. However, if complications are expected from ulcerations, treatment is also required for these forms. As therapy may cause adverse systemic or cutaneous side effects, particularly scarring, sometimes intervention has been reserved for patients with significant complications. Therefore, it is difficult to choose a therapy that eliminates hemangiomas before the development of complications and without systemic side effects [2]. For this reason, the following infantile hemangiomas must be considered as “problem hemangiomas,” for which active treatment is mandatory (Table 10.3):