| Input | System | Output |
| Oxygen/Carbon Dioxide | Kidney | Erythropoietin (EPO) |
| Erythropoietin (EPO) | Bone marrow | Red blood cells |
| Cellular damage | Liver | C-reactive protein (CRP) |
| C-reactive protein (CRP) | Bone marrow | Neutrophils (White blood cells) |
| Unconjugated bilirubin | Liver | Conjugated bilirubin |
| Antigen | T-cell lymphocyte | ‘Wanted Poster’ complex |
| ‘Wanted Poster’ complex | B-cell lymphocyte | Antibody |
| Thyroid-stimulating hormone | Thyroid | Thyroxine |
Draw a network diagram to show oxygen levels and kidney production of EPO, which induces the bone marrow to make more red blood cells which should carry more oxygen around, thereby reducing the need for more EPO. You can annotate this by adding a family group onto each organ or system.
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