Adenocystic Carcinoma



Figure 15.1
39-year-old Caucasian male with a pink, ulcerated nodule on the right heel





Differential Diagnosis






  • Pyogenic granuloma


  • Basal cell carcinoma


  • Melanoma


  • Metastatic carcinoma


  • Angiosarcoma


  • Atypical fibroxanthoma


  • Spitz nevus


  • Adenocystic carcinoma


  • Squamous cell carcinoma


Biopsy Results

“Suggestive of adenocystic carcinoma.”


Diagnosis

Adenocystic carcinoma


Microscopic Feature


The classic findings of cutaneous adenocystic carcinoma (ACC) occur in the deep dermis and are characterized by basaloid cells in islands that form cribriform patterns and tubular structures (Fig. 15.2). Multiple cystic spaces can be seen containing mucin that stains positively with hyaluronic acid (Figs. 15.3 and 15.4). Perineural invasion is observed in most cases. The lumina of the tubular structures have prominent basement membrane material that is PAS positive and diastase-resistant [13].

A330642_1_En_15_Fig2_HTML.jpg


Figure. 15.2
H&E, 40×. Low magnification view shows an ulcerated epidermis with underlying nests of tumor


A330642_1_En_15_Fig3_HTML.jpg


Figure 15.3
H&E, 40×. The tumor is invasive and extends into the deep dermis


A330642_1_En_15_Fig4_HTML.jpg


Figure 15.4
H&E, 400×. A close up of a basaloid nest which contains scattered round, cystic spaces (cookie cutter pattern)

Unlike the similarly appearing adenoid basal cell carcinoma, ACC typically does not have a connection to the overlying epidermis or adnexal structures. This separation is a helpful clue for pathologists when making the diagnosis, as oftentimes these two can be difficult to differentiate. Immunohistochemical studies demonstrate that cutaneous ACC stains positively for S-100, epithelial membrane antigen (EMA), and is occasionally positive for carcinoembryonic antigen (CEA) [13].

Only gold members can continue reading. Log In or Register to continue

Stay updated, free articles. Join our Telegram channel

Nov 17, 2016 | Posted by in ONCOLOGY | Comments Off on Adenocystic Carcinoma

Full access? Get Clinical Tree

Get Clinical Tree app for offline access