Tables of Anti-infective Agent Pharmacology


54

Tables of Anti-infective Agent Pharmacology



Manjunath P. Pai, Joseph S. Bertino Jr.



This chapter serves as a centralized source of pharmacologic information on anti-infective agents. The first table provides an index of all the tables that are included in this chapter (Table 54-1). Tables detailing generic and trade name for anti-infective agents are provided in an alphabetized sequence (Tables 54-2 and 54-3). Tables describing existing dosage formulations are also categorized by chemical or pharmacologic class (Tables 54-4 through 54-16). Available information regarding the usual doses in adults and children, pharmacokinetic information, and dose adjustment in renal impairment is provided by chemical or pharmacologic class (Tables 54-17 through 54-30). Several anti-infective agents are substrates, inducers, and inhibitors of drug metabolism enzymes and transporters. Tables categorizing these potential mechanisms for drug-drug interactions as either the victim or perpetrator drug are included (Tables 54-31 through 54-35).



TABLE 54-1


Index of Tables Included in This Chapter





















































































































TABLE NUMBER TABLE TITLE
Anti-infective Names (organized alphabetically)
54-2 Generic and Trade Names
54-3 Trade and Generic Names
Anti-infective Dosage Forms
54-4 Penicillin Dosage Forms
54-5 Cephalosporin Dosage Forms
54-6 Aminoglycoside Dosage Forms
54-7 Tetracycline and Related Products Dosage Forms
54-8 Macrolide, Azalide, Ketolide, Lincosamide, Chloramphenicol, and Metronidazole Dosage Forms
54-9 Miscellaneous Agent Dosage Forms
54-10 Folate Antagonist Dosage Forms
54-11 Quinolone and Urinary Anti-infective Dosage Forms
54-12 Antimycobacterial Dosage Forms
54-13 Antifungal Dosage Forms
54-14 Antiparasitic Dosage Forms
54-15 Antiviral Dosage Forms
54-16 Antiretroviral Dosage Forms
Clinical Pharmacology
54-17 Anti-infective Agent Pharmacology: Penicillins
54-18 Anti-infective Agent Pharmacology: Cephalosporins
54-19 Anti-infective Agent Pharmacology: Miscellaneous β-Lactams
54-20 Anti-infective Agent Pharmacology: Aminoglycosides
54-21 Anti-infective Agent Pharmacology: Tetracyclines and Glycyclines
54-22 Anti-infective Agent Pharmacology: Azalides, Macrolides, Ketolides, Lincosamides, Chloramphenicol, and Metronidazole
54-23 Anti-infective Agent Pharmacology: Miscellaneous Gram-Positive Agents and Polymyxins, Fusidic Acid
54-24 Anti-infective Agent Pharmacology: Sulfonamides and Trimethoprim
54-25 Anti-infective Agent Pharmacology: Quinolones and Urinary Anti-infectives
54-26 Anti-infective Agent Pharmacology: Antimycobacterials
54-27 Anti-infective Agent Pharmacology: Antifungal Agents
54-28 Anti-infective Agent Pharmacology: Antiparasitic Agents
54-29 Anti-infective Agent Pharmacology: Antiviral Agents
54-30 Anti-infective Agent Pharmacology: Antiretroviral Agents
Drug-Drug Interactions
54-31 Key Drug Substrates by Cytochrome P-450 (CYP) Drug Metabolizing Isozymes
54-32 Drug Inhibitors by Cytochrome P-450 (CYP) Drug Metabolizing Isozymes
54-33 Drug and Chemical Inducers by Cytochrome P-450 (CYP) Drug Metabolizing Isozymes
54-34 Select Drug Transporter Localization with Representative Substrates, Inducers, and Inhibitors
54-35 Adverse Drug Interactions Involving Anti-infective Agents


TABLE 54-2


Generic and Trade Names









































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































GENERIC NAME TRADE NAME CLASS
Abacavir Epzicom,* Kivexa,* Trizivir,* Ziagen, Ziagenavir Antiretroviral
Acyclovir Lipsovir,* Zovirax Antiviral
Adefovir dipivoxil Hepsera Antiviral
Albendazole Albenza, Eskazole, Zentel Antiparasitic
Amantadine hydrochloride Symadine, Symmetrel Antiviral
Amdinocillin Coactin Penicillin
Amikacin sulfate Biclin, Biklin, Likacin Aminoglycoside
Aminosalicylic acid Paser Antimycobacterial
Amoxicillin Amoxil, Clamoxyl, Doxamil, Hiconcil, Polymox, Prevpac,* Trimox Penicillin
Amoxicillin/clavulanate potassium Amoxiclav,* Augmentin,* Augmentin XR,* Calvepen* Penicillin/β-lactamase inhibitor
Amphotericin B Amphocin, Fungilin, Fungizone Antifungal
Amphotericin B cholesteryl sulfate complex Amphotec Antifungal
Amphotericin B lipid complex Abelcet Antifungal
Amphotericin B liposomal AmBisome Antifungal
Ampicillin Penicillin
Ampicillin sodium Polycillin-N, Totacillin-N Penicillin
Ampicillin trihydrate Polycillin, Totacillin Penicillin
Ampicillin/probenecid Probampacin* Penicillin/tubular secretion inhibitor
Ampicillin/sulbactam Bacimex,* Combactam,* Unasyn* Penicillin/β-lactamase inhibitor
Anidulafungin Eraxis Antifungal
Artemether Coartem,* Paluther, Riamet* Antimalarial
Artesunate Plasmotrim (CDC) Antimalarial
Atazanavir Reyataz Protease inhibitor
Atovaquone Mepron, Wellvone Antiparasitic
Atovaquone/proguanil Malarone* Antimalarial
Azithromycin Azitromax, Sumamed, Zithromax, Zithromax Tri-Pak, Zitromax, Zmax, Z-Pak Azalide
Azlocillin Securopen Penicillin
Aztreonam Azactam, Monobac, Primbactam, Urobactam Monobactam
Bacampicillin Ambaxin, Bacampicin, Penglobe, Spectrobid Penicillin
Bacitracin Baci-IM Polypeptide
Balofloxacin Baloxin Fluoroquinolone
Bithionol Bitin, Lorothidol (CDC) Antiparasitic
Boceprevir Victrelis Antiviral (hepatitis C)
Butoconazole nitrate Femstat 3, Gynazole-1, Gynomyk, Mycelex-3 Antifungal
Capreomycin sulfate Capastat Sulfate Antimycobacterial
Carbenicillin indanyl sodium Penicillin
Carbol-fuchsin Fungol Antifungal
Caspofungin Cancidas Antifungal
Cefaclor Distaclor, Keftid, Vercef Cephalosporin
Cefadroxil Baxam, Cefamox, Duracef, Duricef, Ultracef Cephalosporin
Cefamandole nafate Mandokef, Mandol Cephalosporin
Cefazolin sodium Ancef, Cefacidal, Cefamezin, Zolicef Cephalosporin
Cefdinir Cefzon, Omnicef Cephalosporin
Cefditoren pivoxil Spectracef Cephalosporin
Cefepime Maxcef, Maxipime Cephalosporin
Cefixime Cefspan, Denvar, Suprax Cephalosporin
Cefonicid sodium Monocid Cephalosporin
Cefoperazone sodium Cefobid, Cefodie, Cefoperazin* Cephalosporin
Cefoperazone/sulbactam Sulperazon,* Sulperazone* Cephalosporin/β-lactamase inhibitor
Ceforanide Precef Cephalosporin
Cefotaxime sodium Claforan Cephalosporin
Cefotetan disodium Cephalosporin
Cefoxitin sodium Mefoxitin Cephalosporin
Cefpirome Cedixen, Cefrom, Cefron Cephalosporin
Cefpodoxime proxetil Orelox, Podomexef, Vantin Cephalosporin
Cefprozil Cefzil, Procef Cephalosporin
Cefsulodin Cefomonil, Monaspor Cephalosporin
Ceftaroline Teflaro Cephalosporin
Ceftazidime Ceptaz, Fortam, Fortaz, Fortum, Kefadim, Tazicef, Tazidime Cephalosporin
Ceftibuten Cedax, Keimax Cephalosporin
Ceftizoxime sodium Cefizox Cephalosporin
Ceftobiprole Zeftera Cephalosporin
Ceftriaxone sodium Rocephalin, Rocephin, Rocephine Cephalosporin
Cefuroxime axetil Ceftin, Zinnat Cephalosporin
Cefuroxime sodium Kefurox, Zinacef Cephalosporin
Cephalexin Cefanex, Ceporex, Keflex Cephalosporin
Cephalothin sodium Ceporacin, Keflin Cephalosporin
Cephapirin sodium Cefadyl Cephalosporin
Cephradine Anspor, Lisacef, Velosef Cephalosporin
Chloramphenicol Chloromycetin Chloramphenicol
Chloramphenicol palmitate Chloromycetin Palmitate Chloramphenicol
Chloramphenicol sodium succinate Chloromycetin Sodium Succinate Chloramphenicol
Chloroquine hydrochloride Aralen Hydrochloride Antimalarial
Chloroquine phosphate Aralen Phosphate Antimalarial
Ciclopirox Loprox Antifungal
Cidofovir Vistide Antiviral
Cinoxacin Quinolone
Ciprofloxacin hydrochloride Ciflox, Ciloxan, Cipro, Ciprodex,* Cipro HC,* Ciproxin, Cipro XR, Proquin XR Fluoroquinolone
Ciprofloxacin lactate Cipro IV Fluoroquinolone
Clarithromycin Biaxin, Biaxin XL, Biclar, Klacid, Prevpac,* Zeclar Macrolide
Clindamycin hydrochloride Cleocin, Dalacin C Lincosamide
Clindamycin palmitate hydrochloride Cleocin Pediatric Lincosamide
Clindamycin phosphate Cleocin Phosphate Lincosamide
Clioquinol Corque,* Diproform* Antifungal
Clofazimine Lampren, Lamprene Antimycobacterial
Clotrimazole Canesten, Cruex, Desenex, FemCare, Fungoid, Gyne-Lotrimin, Lotrimin, Lotrisone, Mycelex Antifungal
Cloxacillin sodium Bactopen, Cloxapen, Orbenin Penicillin
Colistimethate sodium Coly-Mycin M Polymyxin
Cyclacillin Calthor, Cyclapen Penicillin
Cycloserine Seromycin Antimycobacterial
Dapsone Sulfone
Daptomycin Cidecin, Cubicin, Dapcin Cyclic lipopeptide
Darunavir Prezista Antiretroviral
Dehydroemetine Mebadin (CDC) Amebicide
Delavirdine Rescriptor Antiretroviral
Demeclocycline hydrochloride Declomycin Tetracycline
Dicloxacillin sodium Diclocil, Dycill, Pathocil Penicillin
Didanosine Videx, Videx EC Antiretroviral
Diethylcarbamazine Hetrazan, DEC (CDC) Antiparasitic
Diloxanide furoate Entamide, Furamide Antiparasitic
Dirithromycin Dynabac, Dynabac D5-Pak Macrolide
Dolutegravir Tivicay Antiretroviral
Doripenem Doribax, Finibax Carbapenem
Doxycycline calcium Vibramycin Calcium Tetracycline
Doxycycline hyclate Doryx, Doxy 100, Doxy Caps, Periostat, Vibramycin Hyclate, Vibra-Tabs Tetracycline
Doxycycline monohydrate Vibramycin Monohydrate, Monodox Tetracycline
Econazole nitrate Ecostatin, Gyno-Pevaryl, Pevisone, Spectazole Antifungal
Efavirenz Atripla,* Stocrin, Sustiva, Viraday* Antiretroviral

Atripla,* Coviracil, Emtriva, Truvada,* Viraday* Antiretroviral
Elvitegravir Stribild* Antiretroviral
Emtricitabine Emtriva, Stribild,* Truvada,* Complera* Antiretroviral
Enfuvirtide Fuzeon Fusion inhibitor
Enoxacin Comprecin, Enoxor, Penetrex Fluoroquinolone
Entecavir Baraclude Antiviral
Ertapenem Invanz Carbapenem
Erythromycin Akne-Mycin, Benzamycin,* E-Base, E-Mycin, ERYC, Ery-Tab, PCE, Robimycin Macrolide
Erythromycin estolate Ilosone Macrolide
Erythromycin ethylsuccinate E.E.S., EryPed, Eryzole,* E.S.P.,* Pediazole,* Sulfimycin* Macrolide
Erythromycin gluceptate Ilotycin Macrolide
Erythromycin lactobionate Erythrocin Macrolide
Erythromycin stearate Erythrocin Stearate, Wyamycin Macrolide
Ethambutol hydrochloride Myambutol, Servambutol Antimycobacterial
Ethionamide Trecator Antimycobacterial
Etravirine Intelence Antiretroviral
Famciclovir Famvir Antiviral
Fidaxomicin Dificid Macrolide
Flomoxef Flumarin Cephalosporin
Flucloxacillin Floxapen, Flucil, Flucillin, Fluclox Penicillin
Fluconazole Diflucan Antifungal
Flucytosine Ancobon, Ancotil Antifungal
Fosamprenavir Lexiva, Telzir Antiretroviral
Foscarnet sodium Foscavir Antiviral
Fosfomycin tromethamine Monuril, Monurol Urinary anti-infective
Furazolidone Furoxone Antiprotozoal
Ganciclovir sodium Cymevene, Cytovene, Vitrasert Antiviral
Gatifloxacin Zymar Fluoroquinolone
Gemifloxacin Factive Fluoroquinolone
Gentamicin sulfate Cidomycin, Garamycin, Genoptic, Jenamicin, Storz-G Aminoglycoside
Gentian violet Antifungal
Griseofulvin Fulcin, Fulvicin P/G, Fulvicin U/F, Grifulvin V, Grisactin, Grisactin Ultra, Grisovin, Gris-PEG Antifungal
Halofantrine Halfan Antiparasitic
Hydroxychloroquine sulfate Plaquenil Sulfate Antimalarial
Imipenem/cilastatin Primaxin,* Tienam* Carbapenem
Indinavir Crixivan Protease inhibitor
Interferon alfa-2a recombinant Roferon-A Antiviral
Interferon alfa-2b recombinant Intron A, Rebetron* Antiviral
Interferon alfacon-1 Infergen Antiviral
Interferon alfa-n3 Alferon N Antiviral
Iodoquinol Yodoxin M, Yodoxin Amebicide
Isoniazid Laniazid, Nydrazid, Rifamate,* Rifater,* Rifinah,* Rimactane/INH* Antimycobacterial
Itraconazole Sporanox Antifungal
Ivermectin Mectizan, Stromectol Antiparasitic
Josamycin Josalid Macrolide
Kanamycin sulfate Anamid Aminoglycoside
Ketoconazole Fungoral, Nizoral Antifungal
Lamivudine (3TC) Combivir,* Epivir, Epivir-HBV, Epzicom,* Kivexa,* Trizivir,* Zeffix Antiretroviral
Levofloxacin Cravit, Levaquin, Quixin, Tavanic Fluoroquinolone
Lincomycin hydrochloride Lincocin Lincosamide
Linezolid Zyvox, Zyvoxam Oxazolidinone
Lomefloxacin hydrochloride Maxaquin, Okacin, Uniquin Fluoroquinolone
Lopinavir/ritonavir Kaletra* Antiretrovirals
Loracarbef Lorabid Carbacephem
Lumefantrine Coartem* Antimalarial
Mafenide Sulfamylon Sulfonamide
Maraviroc Selzentry, Celsentri Antiretroviral
Mebendazole Anthelmintic
Mefloquine Lariam Antimalarial
Meglumine antimonate Glucantim, Glucantime Antiparasitic
Melarsoprol Arsobal, Mel B (CDC) Antiparasitic
Meropenem Meronem, Merrem Carbapenem
Methacycline Rondomycin Tetracycline
Methenamine hippurate Hiprex, Urex Urinary anti-infective
Methenamine mandelate Mandelamine Urinary anti-infective
Metronidazole Elyzol, Flagyl, Flagyl ER, Flagyl 375, Helidac,* MetroGel, Protostat, Rozex Nitroimidazole
Mezlocillin sodium Baypen Penicillin
Micafungin Mycamine Antifungal
Miconazole Daktacort,* Daktarin, Gyno-Daktarin, Micatin, Monistat Antifungal
Minocycline hydrochloride Dynacin, Minocin, Myrac, Vectrin Tetracycline
Moxalactam Moxam Cephalosporin
Moxifloxacin Avelox, Vigamox Fluoroquinolone
Mupirocin Bactroban Pseudomonic acid
Nadifloxacin Acuatim, Nadoxin, Nadixa Fluoroquinolone
Nafcillin sodium Nafcil, Unipen Penicillin
Naftifine Naftin Antifungal
Nalidixic acid NegGram Quinolone
Natamycin Natacyn Antifungal
Nelfinavir Viracept Protease inhibitor
Neomycin sulfate Kenacomb,* Maxitrol,* Mycifradin Sulfate, Neosporin* Aminoglycoside
Netilmicin sulfate Netilyn, Netromycin Aminoglycoside
Nevirapine Viramune Antiretroviral
Niclosamide Niclocide, Yomesan Anthelmintic
Nifurtimox Bayer 2502, Lampit (CDC) Antiparasitic
Nitazoxanide Alinia Antiprotozoal
Nitrofurantoin Furadantin, Macrobid, Macrodantin Urinary anti-infective
Norfloxacin Floxacin, Noroxin Fluoroquinolone
Novobiocin sodium Albamycin
Nystatin Kenacomb,* Mycostatin, Mycostatin Filmlok, Nilstat Antifungal
Ofloxacin Exocin, Floxin, Ocuflox, Tarivid Fluoroquinolone
Oritavancin diphosphate Glycopeptide
Oseltamivir phosphate Tamiflu Antiviral
Oxacillin sodium Penicillin
Oxamniquine Mansil Anthelmintic
Oxiconazole nitrate Oxistat Antifungal
Oxolinic acid Oribiox Quinolone
Oxytetracycline hydrochloride Uri-Tet, Urobiotic Tetracycline
Palivizumab Synagis Antiviral
Paromomycin sulfate Humatin Amebicide
Pazufloxacin Pasil, Pazucross Fluoroquinolone
Pefloxacin Peflacine, Peflox Fluoroquinolone
Peginterferon alfa-2a Pegasys Antiviral
Peginterferon alfa-2b Pegetron,* PEG-Intron Antiviral
Penciclovir Denavir, Vectavir Antiviral
Penicillin G benzathine Bicillin,* Bicillin C-R,* Bicillin C-R 900/300,* Bicillin L-A, Permapen Penicillin
Penicillin G + phenoxymethyl penicillin Kesso-pen* Penicillin
Penicillin G potassium Pfizerpen Penicillin
Penicillin G procaine Bicillin C-R,* Bicillin C-R 900/300,* Crysticillin AS, Pfizerpen-AS, Wycillin Penicillin
Penicillin G sodium Penicillin
Penicillin V potassium Penicillin
Pentamidine isethionate NebuPent, Pentacarinat, Pentam Antiprotozoal
Phenazopyridine/sulfisoxazole Azo Gantrisin* Symptomatic bladder therapy/sulfonamide
Pipemidic acid Dolcol Quinolone
Piperacillin sodium Pipracil, Pipril Penicillin
Piperacillin sodium/tazobactam sodium Tazocin,* Zosyn* Penicillin/β-lactamase inhibitor
Piperazine citrate Anthelmintic
Pivmecillinam Mecillin 200, Selexid Penicillin
Polymyxin B sulfate Aerosporin, Neosporin* Polymyxin
Posaconazole Noxafil Antifungal
Praziquantel Biltricide Anthelmintic
Primaquine phosphate Antimalarial
Proguanil Paludrine Antiparasitic
Pyrantel pamoate Antiminth, Ascarel, Combantrin, Pin-X, Reese’s Pinworm Medicine Anthelmintic
Pyrazinamide Rifater,* Zinamide Antimycobacterial
Pyrimethamine Daraprim Antimalarial
Quinacrine hydrochloride Atabrine Anthelmintic
Quinine sulfate Qualaquin Antimalarial
Quinupristin/dalfopristin Synercid* Streptogramin
Raltegravir Isentress Antiretroviral
Retapamulin Altabax Anti-impetigo
Ribavirin Copegus, Pegetron,* Rebetol, Rebetron,* Ribasphere, Virazole Antiviral
Rifabutin Mycobutin Antimycobacterial
Rifampin Rifadin, Rifamate,* Rifinah,* Rimactane, Rimactane/INH* Antimycobacterial
Rifapentine Priftin Antimycobacterial
Rifaximin Lumenax, Xifaxan Rifamycin
Rilpivirine Complera,* Edurant Antiretroviral
Rimantadine Flumadine, Roflual Antiviral
Ritonavir Norvir Protease inhibitor
Rosoxacin Eradacil Quinolone
Roxithromycin Rulid, Rulide, Surlid Macrolide
Rufloxacin Uroflox Fluoroquinolone
Saquinavir Fortovase, Invirase Protease inhibitor
Sertaconazole Ertaczo Antifungal
Silver sulfadiazine Silvadene, Thermazene Sulfonamide
Sitafloxacin Gracevit Fluoroquinolone
Sodium stibogluconate Pentostam (CDC) Antiparasitic
Sodium thiosulfate Versiclear Antifungal
Sparfloxacin Zagam Fluoroquinolone
Spiramycin Rovamycin, Rovamycine Macrolide
Stavudine (d4T) Zerit Antiretroviral
Streptomycin sulfate Aminoglycoside
Sulconazole Exelderm Antifungal
Sulfabenzamide/sulfacetamide/sulfathiazole Sultrin,* Triple Sulfa* Sulfonamide
Sulfadiazine Sulfonamide
Sulfamethizole Sulfonamide
Sulfamethoxazole Sulfonamide
Sulfanilamide AVC Sulfonamide
Sulfisoxazole Azo-Sulfisoxazole,* Gantrisin Sulfonamide
Sulfisoxazole acetyl Eryzole,* Pediazole* Sulfonamide
Suramin Antrypol, Belganyl, Germanin, Naphuride (CDC) Antiparasitic
Teicoplanin Targocid Glycopeptide


Lipoglycopeptide
Telaprevir Incivek Antiviral (hepatitis C)
Telavancin Vibativ Lipopeptide
Telbivudine Tyzeka Antiviral
Telithromycin Ketek Ketolide
Tenofovir Atripla,* Complera,* Stribild,* Truvada,* Viraday,* Viread Antiretroviral
Terbinafine Lamisil Antifungal
Terconazole Terazol, Zazole Antifungal
Tetracycline hydrochloride Achromycin V, Helidac,* Panmycin, Robitet, Sumycin, Tetrachel, Tetralan Tetracycline
Thiabendazole Mintezol Anthelmintic
Thiacetazone Antimycobacterial
Ticarcillin disodium Tarcil Penicillin
Ticarcillin disodium/clavulanate potassium Timentin* Penicillin/β-lactamase inhibitor
Tigecycline Tygacil Glycylcycline
Tinidazole Tindamax Antiparasitic
Tioconazole Vagistat-1 Antifungal
Tipranavir Aptivus Antiretroviral
Tobramycin sulfate Nebcina, Obracin, TobraDex,* Tobrex Aminoglycoside
Tobramycin inhalation solution TOBI Aminoglycoside
Tolnaftate Mycil,* Tinactin, Tinaderm Antifungal
Tosufloxacin Ozex, Tosacin Fluoroquinolone
Trifluridine Viroptic Antiviral
Trimethoprim Monotrim, Primsol, Proloprim, Trimopan, Trimpex Folate antagonist
Trimethoprim/
sulfamethoxazole
Bactrim,* Bactrim DS,* Cotrim,* Cotrim D.S.,* Septra,* Septra DS,* Sulfatrim,* Sulfoxaprim,* Uroplus* Folate antagonists
Trimetrexate glucuronate NeuTrexin Antiprotozoal
Tripanavir Aptivus Antiretroviral
Trisulfapyrimidines Sulfonamide
Troleandomycin Tao Macrolide
Undecylenic acid Fungi-Nail Antifungal
Valacyclovir Valtrex, Zelitrex Antiviral
Valganciclovir Valcyte Antiviral
Vancomycin hydrochloride Lyphocin, Vancocin, Vancoled, Vancor Glycopeptide
Vidarabine Vira-MP Antiviral
Voriconazole Vfend Antifungal
Zanamivir Relenza Antiviral
Zidovudine Combivir,* Retrovir, Trizivir* Antiretroviral


* A combination product.

Only gold members can continue reading. Log In or Register to continue

Stay updated, free articles. Join our Telegram channel

Jul 1, 2017 | Posted by in INFECTIOUS DISEASE | Comments Off on Tables of Anti-infective Agent Pharmacology

Full access? Get Clinical Tree

Get Clinical Tree app for offline access