Part of “CHAPTER 66 – RARE DISORDERS OF SKELETAL FORMATION AND HOMEOSTASIS“

Osteopoikilosis (spotted bones) is a radiographic curiosity.5,6 If unrecognized, however, it may lead to investigation for metastatic disease, mastocytosis, tuberous sclerosis, or other disorders. It is inherited as an autosomal dominant trait and manifests as numerous well-defined, small, homogeneous, symmetric, round or oval, periarticular foci of osteosclerosis (Fig. 66-6). Bone scanning, however, is unremarkable.49 In some kindreds focal, asymptomatic accumulation of dermal elastin (dermatofibrosis lenticularis disseminata) is found, and the disorder is called Buschke-Ollendorff syndrome.50