Nonenveloped (Naked) RNA Viruses

Chapter 23

Nonenveloped (Naked) RNA Viruses


• This family of small viruses with a naked, icosahedral capsid and single-stranded (+) RNA genome includes the enteroviruses and rhinoviruses.

• The enteroviruses are acid stable, can survive in the gastrointestinal (GI) tract, and are transmitted primarily by the fecal-oral route.

1. Pathogenesis (Fig. 23-1)

2. Diseases due to enteroviruses (Box 23-1)

• Poliomyelitis

a. Usually caused by poliovirus but also Coxsackie A virus

b. Abortive poliomyelitis (minor illness)

c. Nonparalytic poliomyelitis (aseptic meningitis): fever, headache, sore throat, stiff neck, pleocytosis of cerebrospinal fluid (CSF)

d. Paralytic poliomyelitis (major illness): same symptoms as nonparalytic polio plus flaccid paralysis resulting from destruction of lower motor neurons

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Jun 18, 2016 | Posted by in IMMUNOLOGY | Comments Off on Nonenveloped (Naked) RNA Viruses

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