Many risk factors associated with the appearance of adverse events during CRS plus HIPEC are described by many authors. However it is not possible to compare the various series due to the numerous variables used by the different authors. Consequently, we report the most representative series: Kusamura et al. [6], using univariate analysis, found the following variables have a statistically significant correlation with major morbidity: male gender (p = 0.016), Eastern Cooperative Oncology Group (ECOG) performance status (p = 0.05), no previous systemic chemotherapy (p = 0.004), carcinomatosis extent (p = 0.027), number of bowel anastomoses > 2 (p = 0.028), procedure duration (p = 0.014), extent of cytoreduction (p = 0.019), and cisplatin (CDDP) dose for intraperitoneal hyperthermic perfusion > 240 mg (p = 0.02). However, in multivariate analysis, no previous systemic chemotherapy [odds ratio (OR) 2.719; 95% confidence interval (CI) 0.984–7.512; p = 0.054], extent of cytoreduction (OR 2.877; 95% CI 1.292–6.404; p = 0.01), and CDDP dose > 240 mg (OR 3.128; 95% CI 1.239–7.900; p = 0.016) were independent risk factors for major morbidity. Glehen et al. [9] carried out only a univariate analysis in which they found that major morbidity was statistically linked with carcinomatosis stage (p = 0.016), duration of surgery (p = 0.005), and number of resections and peritonectomy procedures (p = 0.042). Hansson et al., [10], in their multivariate analysis, observed the adverse events were associated with stoma formation, duration of surgery, perioperative blood loss, and Peritoneal Cancer Index (PCI). Casado-Adam et al. [11], in their univariate analysis, found a statistically significant correlation between morbidity, histological grade (p = 0.0166), PCI (p = 0.0049), small-bowel resections (p = 0.0493), colorectal anastomosis (p = 0.0430), and the number of anastomoses performed per patient (p = 0.0288). However, multivariate analysis showed that PCI was the only independent risk factor for gastrointestinal complications (p = 0.0586). Finally, Mizumoto et al. [12], in their univariate analysis, showed that PCI > 20, operation time > 5 h, and blood loss > 2.5 L were significant risk factors for postoperative complications. On the other hand, the complication rate in patients who received HIPEC was significantly lower than in patients treated without HIPEC. Gender, age >/< 65 years old, origin of peritoneal carcinomatosis (PC), and completeness of cytoreduction were not related to morbidity. Multivariate analysis showed that PCI higher than 20 was the only significant factor that increased the occurrence of postoperative complications. PCI > 20 was associated with 2.8 times increased risk of postoperative complications. In multivariate analysis, patients who received HIPEC showed significantly lower mortality and morbidity rates than patients who did not.