Metastasectomy for Stage IV Melanoma

Metastatic melanoma has an unpredictable natural history but a predictably high mortality. Despite recent advances in systemic therapy, many patients do not respond, or develop resistance to drug therapy. Surgery has consistently shown good outcomes in appropriately selected patients. It is likely to be even more successful in the era of more effective medical treatment. Surgery should remain a strongly considered option for metastatic melanoma.

Key points

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Outcomes are poor for most patients with stage IV metastatic melanoma.
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Surgery provides well-selected patients with a significantly improved chance at long disease-free and overall survival.
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Surgery will continue to serve as a complement to investigational and approved immunotherapeutic and targeted approaches.