Markers and Immunoprofile of Tumors of the Oral Cavity and Salivary Gland Tumors

, Hans Guski² and Glen Kristiansen³

(1)

Carl-Thiem-Klinikum, Institut für Pathologie, Cottbus, Germany

(2)

Vivantes Klinikum Neukölln, Institut für Pathologie, Berlin, Germany

(3)

Universität Bonn, UKB, Institut für Pathologie, Bonn, Germany

6.1 Odontogenic Tumors and Tumors of the Oral Cavity

Diagnostic Antibody Panel for Odontogenic Tumors and Tumors of the Oral Cavity

Cytokeratin profile, p63, p40, EBV, p16

Immunoprofile of odontogenic tumors and tumors the oral cavity
Tumor type	+ in >90% (+)	+ in 50–90% (±)	+ in 10–50% (∓)	+ in <10% (−)
Basal cell carcinoma	Epithelial specific antigen (BerEP4), bcl-2, androgen receptors			EMA, CEA
Squamous cell carcinoma	CK5/6, CK8, CK14, CK18, CK19, p63, p40		EBV	CK7, CK20
Sebaceous carcinoma	Adipophilin, EMA, androgen receptors, CEA
Ectomesenchymal chondromyxoid tumor of the tongue	GFAP, Pan-CK, vimentin	S100	Actin	EMA, CK7, p63, calponin, desmin
Ameloblastoma	Pan-CK, CK5, CK14, vimentin	Calretinin
Clear cell odontogenic carcinoma	CK8, CK 13, CK14, CK18, CK19, EMA			Vimentin, desmin, actin, S100, HMB45
Granular cell tumor	S100, SOX-10, CD56, CD68, NSE, vimentin	Inhibin		Pan-CK, actin, HMB-45

The immunoprofile of miscellaneous soft tissue tumors arising in the oral cavity are listed in related sections.

6.2 Salivary Gland Tumors

Diagnostic Antibody Panel for Salivary Gland Tumors

α-Amylase, CD117, GFAP, GATA-3, DOG-1, cytokeratin profile, p63, EMA, sm-actin, h-caldesmon, calponin, S100 [1–3]

Cytokeratin Profile

Salivary glands are composed of luminal cells including ductal and acinar cells in addition to the myoepithelial cells. The cytokeratin profile is an important tool to highlight the different cell types forming salivary gland units or tumors derived from these cell types. High molecular weight cytokeratins (CK5/10/14) label the myoepithelial and basal cells. p63, actin, and myosin are also additional markers that label these cells. Recently Sox-10 is also found to label the myoepithelial cells. Cytokeratin 7 is a marker for acinar and ductal cells. The atypical distribution of these cell types is clearly seen in tumors composed of both cell types (Fig. 6.1).

Fig. 6.1

Cytokeratin expression pattern in adenoid cystic carcinoma; CK7, HE, p63. Lumenal ductal cells positive for CK7 (left), basal cells labeled by p63 (right)

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