Markers and Immunoprofile of Thymic Epithelial Tumors

, Hans Guski2 and Glen Kristiansen3



(1)
Carl-Thiem-Klinikum, Institut für Pathologie, Cottbus, Germany

(2)
Vivantes Klinikum Neukölln, Institut für Pathologie, Berlin, Germany

(3)
Universität Bonn, UKB, Institut für Pathologie, Bonn, Germany

 



Diagnostic Antibody Panel for Thymic Epithelial Tumors


  1. 1.


    Markers for thymic epithelium: PAX-8, CD117, CD5, cytokeratin profile (high molecular weight cytokeratins), p63

     

  2. 2.


    Markers for lymphoid stroma: CD1a, CD3, TdT [1, 2]

     

PAX-8 and CD117 are two markers helpful to discriminate between normal thymic epithelium and neoplastic thymic epithelium, which is positive for both markers, whereas other epithelial cells or carcinoma types are negative for both markers (Figs. 4.1, 4.2, 4.3, and 4.4).

A430796_1_En_4_Fig1_HTML.jpg


Fig. 4.1
Nuclear PAX-8 expression in neoplastic epithelial cells of AB thymoma type

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Dec 25, 2017 | Posted by in ONCOLOGY | Comments Off on Markers and Immunoprofile of Thymic Epithelial Tumors

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