Part of “CHAPTER 66 – RARE DISORDERS OF SKELETAL FORMATION AND HOMEOSTASIS“

Unifocal or multifocal osteolytic lesions manifest in a variety of sporadic idiopathic or hereditary disorders.87 Acro-osteolysis occurs with polyvinyl chloride poisoning, hand trauma (e.g., use of vibrating instruments), systemic lupus erythematosus, and other conditions.87,88 Carpotarsal osteolysis (Fig. 66-16) is characterized by episodes of pain and swelling in the wrists and ankles during childhood that accompany osteolysis of predominantly the carpal and tarsal bones.89 The disorder occurs as an isolated problem when transmitted as an autosomal dominant trait; nephropathy occurs in some sporadic or autosomal recessive cases. In Gorham massive osteolysis, unifocal areas of osteolysis can cause considerable bone destruction.90