The most prominent removal mechanism for released NE is reuptake into the presynaptic terminal by a nonstereospecific, energy-requiring process called uptake-1.14,15 Cocaine, tricyclic antidepressants (e.g., desipramine hydrochloride), and ouabain inhibit uptake-1. The hypotensive effect of guanethidine and the hypertensive effect of tyramine depend on uptake of these drugs into presynaptic axons. Therefore, the administration of uptake-1 inhibitors attenuates these effects. Molecular genetic studies have confirmed the existence of a family of neurotransmitter transporters, including distinct transporters for DA and NE. Uptake-1 refers to the transporter for NE in sympathetic nerves.

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Aug 25, 2016 | Posted by in ENDOCRINOLOGY | Comments Off on CATECHOLAMINE REMOVAL

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