FIGO stages
TNM categories
Primary tumour cannot be assessed
TX
No evidence of primary tumour
T0
0
Carcinoma in situ (preinvasive carcinoma)
Tis
I
Cervical carcinoma confined to uterus (extension to corpus should be disregarded)
T1
IA
Invasive carcinoma diagnosed only by microscopy. All macroscopically visible lesions – even with superficial invasion – are stage IB/T1b
T1a
IA1
Stromal invasion no greater than 3.0 mm in depth and 7.0 mm or less in horizontal spread
T1a1
IA2
Stromal invasion more than 3.0 mm and not more than 5.0 mm with a horizontal spread 7.0 mm or lessa
T1a2
IB
Clinically visible lesion confined to the cervix or microscopic lesion greater than IA2/T1a2
T1b
IB1
Clinically visible lesion 4.0 cm or less in greatest dimension
T1b1
IB2
Clinically visible lesion more than 4 cm in greatest dimension
T1b2
II
Tumour invades beyond the uterus but not to pelvic wall or to lower third of the vagina
T2
IIA
Without parametrial invasion
T2a
IIB
With parametrial invasion
T2b
III
Tumour extends to pelvic wall and/or involves lower third of vagina and/or causes hydronephrosis or non-functioning kidney
T3
IIIA
Tumour involves lower third of vagina, no extension to pelvic wall
T3a
IIIB
Tumour extends to pelvic wall and/or causes hydronephrosis or non-functioning kidney
T3b
IVA
Tumour invades mucosa of bladder or rectum and/or extends beyond true pelvisb
T4
IVB
Distant metastasis
M1
3.2.1 Histology
The majority of primary cervical cancers are squamous cell carcinomas. Adenocarcinomas often occur higher in the endocervical canal but has similar prognosis and management is the same.
4 Treatment for Cervical Cancer
The decision about treatment for invasive cancer is best decided by multidisciplinary teams represented by gynaecologists, oncologists and radiologists. It is good practice to review histology of selected cases with a dedicated pathologist at a multidisciplinary meeting.
4.1 Surgery
Early invasive cervix carcinoma (up to FIGO stage IIa) may be treated with surgery. The aim of surgery is to preserve normal function and also to ensure complete removal of the tumour with adequate margins. New developments in the surgical management of cervix carcinoma include less radical surgery that may preserve fertility in young patients such as a cold-knife cone biopsy in very early lesions or more complex operations like radical trachelectomy, which entails removal of the cervix whilst maintaining the uterine body, in selected patients. The standard surgery for macroscopic, early cervical carcinoma is a radical hysterectomy with pelvic lymph node dissection. These patients should undergo surgery at a tertiary referral centre. Inappropriate surgical management may necessitate postoperative radiotherapy and thus increase the risk of associated complications.