Cancer


FIGO stages
 
TNM categories
 
Primary tumour cannot be assessed

TX
 
No evidence of primary tumour

T0

0

Carcinoma in situ (preinvasive carcinoma)

Tis

I

Cervical carcinoma confined to uterus (extension to corpus should be disregarded)

T1

 IA

Invasive carcinoma diagnosed only by microscopy. All macroscopically visible lesions – even with superficial invasion – are stage IB/T1b

T1a

  IA1

Stromal invasion no greater than 3.0 mm in depth and 7.0 mm or less in horizontal spread

T1a1

  IA2

Stromal invasion more than 3.0 mm and not more than 5.0 mm with a horizontal spread 7.0 mm or lessa

T1a2

 IB

Clinically visible lesion confined to the cervix or microscopic lesion greater than IA2/T1a2

T1b

  IB1

Clinically visible lesion 4.0 cm or less in greatest dimension

T1b1

  IB2

Clinically visible lesion more than 4 cm in greatest dimension

T1b2

II

Tumour invades beyond the uterus but not to pelvic wall or to lower third of the vagina

T2

 IIA

Without parametrial invasion

T2a

 IIB

With parametrial invasion

T2b

III

Tumour extends to pelvic wall and/or involves lower third of vagina and/or causes hydronephrosis or non-functioning kidney

T3

 IIIA

Tumour involves lower third of vagina, no extension to pelvic wall

T3a

 IIIB

Tumour extends to pelvic wall and/or causes hydronephrosis or non-functioning kidney

T3b

IVA

Tumour invades mucosa of bladder or rectum and/or extends beyond true pelvisb

T4

IVB

Distant metastasis

M1


aNote: The depth of invasion should not be more than 5 mm taken from the base of the epithelium, either surface or glandular, from which it originates. The depth of invasion is defined as the measurement of the tumour from the epithelial-stromal junction of the adjacent most superficial epithelial papilla to the deepest point of invasion. Vascular space involvement, venous or lymphatic, does not affect classification

bNote: The presence of bullous oedema is not sufficient to classify a tumour as T4




3.2.1 Histology


The majority of primary cervical cancers are squamous cell carcinomas. Adenocarcinomas often occur higher in the endocervical canal but has similar prognosis and management is the same.




4 Treatment for Cervical Cancer


The decision about treatment for invasive cancer is best decided by multidisciplinary teams represented by gynaecologists, oncologists and radiologists. It is good practice to review histology of selected cases with a dedicated pathologist at a multidisciplinary meeting.


4.1 Surgery


Early invasive cervix carcinoma (up to FIGO stage IIa) may be treated with surgery. The aim of surgery is to preserve normal function and also to ensure complete removal of the tumour with adequate margins. New developments in the surgical management of cervix carcinoma include less radical surgery that may preserve fertility in young patients such as a cold-knife cone biopsy in very early lesions or more complex operations like radical trachelectomy, which entails removal of the cervix whilst maintaining the uterine body, in selected patients. The standard surgery for macroscopic, early cervical carcinoma is a radical hysterectomy with pelvic lymph node dissection. These patients should undergo surgery at a tertiary referral centre. Inappropriate surgical management may necessitate postoperative radiotherapy and thus increase the risk of associated complications.

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Sep 20, 2016 | Posted by in HEMATOLOGY | Comments Off on Cancer

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