Animal studies were applied to focus on using high-resolution detector with appropriate physics corrections and advanced image reconstruction methods to get high-quality images of great practical importance. For instance, a normal mouse scanned by uMI S-96R PET/CT with 0.5 mCi ¹⁸F–FDG and 10 min of acquisition time was demonstrated good anatomic details and FDG uptake distributions (Fig. 8.3a–d). With the same imaging parameters, a tumor-bearing nude mouse with hepatocellular carcinoma showed a large, well-circumscribed soft tissue mass with heterogeneous FDG uptake (Fig. 8.4a–b). The high-resolution modality was also used to scan dog with ¹⁸F–FDG whole body PET/CT imaging (Fig. 8.5a–d). In particular, the non-gating heart of dog with rest or stress was displayed via a cardiac scan with brilliant metabolic PET imaging (18F–FDG, 5 mCi; scanning time, 3 min; LYSO, 2.4 × 2.4 mm; and matrix, 256 × 256) and high-resolution anatomical CT imaging (kV,120 and mAs, 70). The fusion tools are helpful for displaying powerful PET/CT fusion images, which can locate papillary muscles of the heart of a dog with metabolic profile (Figs. 8.6a–b and 8.6c–e). F-18 NaF whole body bone imaging can display the entire skeletal system with PET, CT multiplanar reformation (MPR), PET/CT fusion, and CT 3D reconstruction modes (Fig. 8.7a–i). In a comparative study, the image quality of whole body bone imaging of a dog scanned by UIH F-18 NaF PET/CT was superior to that of the same dog by the same type of PET/CT from another manufacturer (Fig. 8.8a–f). In addition, UIH F-18 NaF PET/CT imaging can easily detect fractures of the bilateral distal femoral bones of a dog prior to and after operation (Fig. 8.9a–d).

The UIH high-resolution time-of-flight PET/CT provided more doctor-friendly information in oncology, infection, and cardiovascular diseases. The clinical oncology applied PET/CT to diagnose tumor, to search for unknown primary malignant tumor, to perform tumor staging and restaging, and to evaluate therapy response.