Part of “CHAPTER 53 – CALCITONIN GENE FAMILY OF PEPTIDES“

ADM, originating from the CALC-V gene (see Fig. 53-1 and Fig. 53-2), is a 52-amino-acid peptide originally isolated from human adrenal pheochromocytoma.90,91 As is the case for iCT, a significant fraction of circulating immunoreactive ADM (iADM) consists of one or more precursor peptides with potential bioactivity.

ADM is produced by and secreted from vascular endothelium, smooth musclecells, fibroblasts, monocytes/macrophages, and many other cell types.92,93 Immunoreactive ADM has been detected in many tissues throughout the body (e.g., kidney, lung, skin). ADM is cleared by the kidneys. High levels of the hormone are found in the urine, and serum levels increase with renal failure.94